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A Study of Intra-Ophthalmic Artery Topotecan Infusion for the Treatment of Retinoblastoma — IARB1  

Retinoblastoma Clinical Trial

Official title:
A Pilot Study of Intra-Ophthalmic Artery Topotecan Infusion for the Treatment of Retinoblastoma

Clinical Trial Summary

This study will test if giving topotecan directly into the blood vessel of the eye will improve the treatment of retinoblastoma. This method is referred to as "selective intra-ophthalmic artery chemotherapy" (SIOAC).

The goals of this study are:

- To find out if topotecan is an effective treatment for retinoblastoma when delivered directly to the ophthalmic artery (SIOAC delivery)

- To find out what kind of effects (good and bad) can be expected when topotecan is given by SIOAC

- To assess visual pathway function before and after the study therapy

- To learn more about the pharmacology (how your body handles the drug) of topotecan when delivered directly to the ophthalmic artery

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01466855
Study type Interventional
Source Children's Hospital Medical Center, Cincinnati
Contact
Status Terminated
Phase Early Phase 1
Start date October 2011
Completion date October 2015
View Details
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