Clinical Trials Logo

Clinical Trial Summary

Fundus imaging has become an integral tool in retinal diagnosis. Although single-field fundus photography covers a vital region of the retina, it leaves a large portion of the periphery undiscovered.

Ultra-wide-field imaging systems allowed for visualization of peripheral perfusion abnormalities in myopic eyes that were previously unknown.

In Austria, there are two different wide-field imaging systems available. The first device on the market was the Optos (Optos PLC, Dunfermline, UK) and several years later the Clarus 500 (Carl Zeiss, Meditec AG, Jena, Germany) was introduced.


Clinical Trial Description

While both of the studied imaging systems have the possibility of a 200° view of the retina, we would asses if the differences between the two devices affect the extent of retinal periphery view and if ocular ametropies which come with different retinal pathologies would affect the retinal periphery assessment.

Aim: To compare two CE-marked imaging systems concerning the extent of retinal periphery area viewing.

We would like to perform a prospective observational study that would include patients divided into three groups: myopic patients, hyperopic and emmetropic patients.

Fundus photography will be performed using two ultra-wide-field imaging systems (Optos, Daytona, Optos PLC, Dunfermline, UK and Clarus, 500 Carl Zeiss, Meditec AG, Jena, Germany), performed by the same investigator.

All images with sufficient quality will be exported and saved to hard-disk. The difference in periphery view will be investigated as follows: two retinal photos for each patient will be imported into Photoshop CS6 image-editing system (Adobe, version 13.0.0) where the anatomical landmarks will be matched for each image and the borders will be compared to see if there are differences in retinal periphery area viewing between the two devices. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04255732
Study type Interventional
Source Vienna Institute for Research in Ocular Surgery
Contact Oliver Findl, Prof.
Phone +43 1 91021-84611
Email oliver@findl.at
Status Recruiting
Phase N/A
Start date August 7, 2020
Completion date October 2020

See also
  Status Clinical Trial Phase
Recruiting NCT04956237 - Retinal Surgery With or Without Anesthesiologist, Comparison of Surgeon and Patient's Comfort
Recruiting NCT01432847 - Cell Collection to Study Eye Diseases
Active, not recruiting NCT04130841 - Effects of Internal Limiting Membrane Peeling on Visual Function in Epiretinal Membrane Surgery N/A
Recruiting NCT03713268 - Intraoperative OCT Guidance of Intraocular Surgery II
Active, not recruiting NCT03872479 - Single Ascending Dose Study in Participants With LCA10 Phase 1/Phase 2
Active, not recruiting NCT04636307 - Characterization of Retinal Disease Progression in Eyes With Non Proliferative Diabetic Retinopathy in Diabetes Type 2 Using Non-invasive Procedures (CHART)
Not yet recruiting NCT06451068 - Peripheral Retina Robotically Aligned OCT Study N/A
Recruiting NCT02921568 - Side-by-Side Comparison of P200TE and Spectral OCT/SLO on Diseased Eyes N/A
Completed NCT02315170 - Assessment of Novel Intraocular Injection Guide N/A
Completed NCT00069199 - Optical Coherence Tomography Comparative Study N/A
Withdrawn NCT03603990 - Effect of Vitrectomy on the Evolution of Refractory Diabetic Macular Edema N/A
Active, not recruiting NCT04123626 - A Study to Evaluate the Safety and Tolerability of QR-1123 in Subjects With Autosomal Dominant Retinitis Pigmentosa Due to the P23H Mutation in the RHO Gene Phase 1/Phase 2
Withdrawn NCT02445001 - Erythrocyte Ghost Mediated Retinal Diagnosis N/A
Completed NCT01468337 - Topical Interferon Gamma-1b for Central Serous Chorioretinopathy Phase 1/Phase 2
Completed NCT01227993 - Extension Study for the Evaluation of Finasteride in the Treatment of Chronic Central Serous Chorioretinopathy Phase 1/Phase 2
Completed NCT00792259 - Topcon 3D OCT-1000 Optical Coherence Tomography System
Completed NCT00035906 - Research Study in Patients With Persistent Macular Edema Phase 2
Recruiting NCT05158699 - Effectiveness of Periocular Drug Injection in CATaract Surgery Phase 3
Terminated NCT04110015 - Assessment of Visual Function in Ophthalmic Disorders Using Virtual Visual Field Analysis
Recruiting NCT03592017 - Performance of Long-wavelength Autofluorescence Imaging N/A