Quality of Life Measures in Patients With Retinal Degeneration

Retinal Degeneration Clinical Trial

Official title:

Quality of Life Measures in Patients With Retinal Degeneration

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02814435
• Other study ID #: QoLMeasuresIRD
• Status: Completed
• Start date: July 2016
• Est. completion date: October 2017

Study information

• Verified date: November 2018
• Source: University of Oxford
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Inherited retinal degeneration (IRD) is a major cause of blindness and partial loss of vision cases in the UK and starts at an early age. The purpose of this observational study is to use the results of two questionnaires and a computerised test testing contrast sensitivity, to assess the impact of IRD on quality of life. This study will involve collecting data from patients with IRD, but also collecting data from normal controls.

Description:

IRD presents a significant burden on the NHS as well as on the individual and families. IRDs are particularly difficult in a family situation due to guilt and other complex emotions related to inheritance patterns. Poorer mental health has been reported in patients with retinitis pigmentosa, manifesting in a range of ways including stress, depression and anxiety, particularly as the disease progresses. This is most probably caused by the uncertainty of the disease process and the progressive nature of the degeneration.

Recent work has reported that quality of life significantly deteriorates with a drop in visual field diameter of 20 degrees or a drop in visual acuity lower then LogMAR 0.3 (equivalent to 6/12). Contrast sensitivity is often used in conjunction with VA to assess visual capabilities. It is a measure of the ability to see reduced contrast and has a major impact on utility of vision. Relating contrast sensitivity function to quality of life will provide valuable information about whether this aspect of vision is a critical measure for patient health. This is especially important as novel treatments are being developed for the treatment of IRDs.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 90
• Est. completion date: October 2017
• Est. primary completion date: October 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 85 Years

Eligibility

Inclusion Criteria:

• Participant is willing & able to give informed consent for participation in the study.

• Male or female, aged 18 - 85.

• A clinical or genetic diagnosis of retinal degeneration or normal age and sex-matched controls without known retinal disease.

• Able to participate in visual function testing.

Exclusion Criteria:

• The participant may not enter the study if any of the following apply:

• 1) they have a pre-existing amblyopia or squint;

• 2) they have any other retinal problems that may confound the measures assessed.

Related Conditions & MeSH terms

• Retinal Degeneration

Intervention

Other:
• Questionnaire
The participants will answer two questionnaires. These are the NEI VFQ-25 and the DLTV (daily living tasks of vision).
• Computerised contrast sensitivity function test
This test involves the patient identifying whether bars on a screen are horizontal or vertical. It is designed to measure contrast sensitivity.

Locations

Country	Name	City	State
United Kingdom	Oxford Eye Hospital	Oxford

Sponsors (1)

Lead Sponsor	Collaborator
University of Oxford

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Impact of inherited retinal degeneration on quality of life measures.	This will be assessed by comparing questionnaire results between different inherited retinal degeneration types.This will be determined by using ANOVA testing to compare scores caused by different genetic mutations, allowing us to relate mutations causing central versus peripheral visual loss to the quality of life measures.	May 2016 to May 2017
Secondary	Effect of contrast sensitivity function on quality of life.	Contrast sensitivity function will be related to the questionnaire results using ANOVA testing & correlation analysis.	May 2016 to May 2017

External Links

•   Link