Retina Clinical Trial - Extension, Carbidopa-levodopa in Neovascular AMD

Status Completed

Clinical Trial Summary

This protocol is an extension of protocol 0002, Proof of Concept and Dose Ranging Study of carbidopa-levodopa in Neovascular AMD. that is a 3 month study of escalating doses of carbidopa-levodopa in neovascular AMD. This trial is a 9 month extension for patients who successfully complete protocol 0002 and wish to continue carbidopa-levodopa therapy. It will use the two higher dose regimens of protocol 0002. these will be assigned according to how well the higher dose was tolerated in protocol 0002.

Clinical Trial Description

This extension will employ the same medications, measurements, guidelines for anti-VEGF injections and safeguards as in protocol 0002. In combination with protocol 0002, it will provide a total of 12 months of therapy with carbidopa-levodopa. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03197493
Study type	Interventional
Source	Snyder, Robert W., M.D., Ph.D., P.C.
Contact
Status	Completed
Phase	Phase 2
Start date	August 1, 2017
Completion date	July 9, 2020

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT00431691` - Effect of Antioxidants on Ocular Blood Flow, Endothelial Function, and Cytokine Levels in LPS Induced Inflammatory Model in Humans.	Phase 4
Completed	`NCT01157338` - Clinical Significance of Retinal Emboli During Diagnostic and Therapeutic Cardiac Catheterization	N/A
Completed	`NCT03326908` - Description of the Interdigitation Retinal Area by SD-OCT: An Exploratory Study	N/A
Completed	`NCT04794634` - Relationship Between Alzheimer Disease and Diminution of the Three Macular Nervous Retinal Layers	N/A
Recruiting	`NCT05747742` - Effect of Different Intensities of Repeated Low-Level Red-Light Therapy on Choroidal and Retinal Blood Flow Among Adults	N/A
Completed	`NCT00709423` - Effects of Moxaverine and Placebo on Ocular Blood Flow	Phase 2
Completed	`NCT00814008` - The Relationship Between Stage of Diabetic Retinopathy and Retinal Blood Flow in Patients With IDDM During Euglycemic Clamp	Phase 2
Terminated	`NCT04408677` - Normative Data Collection Study of the Zilia Ocular for the Measurement of Oxygen Saturation in the Retina	N/A
Completed	`NCT00451763` - Intravitreal Bevacizumab for Idiopathic Macular Telangiectasia	Phase 3
Completed	`NCT00706927` - Effect of Xalacom® (Latanoprost/Timolol) and Combigan® (Brimonidine/Timolol) Fixed Combination on Intraocular Pressure and Ocular Blood Flow in Patients With Primary Open Angle Glaucoma or Ocular Hypertension	N/A
Recruiting	`NCT02614625` - Spectral-domain Optical Coherence Tomography of the Eye	N/A
Completed	`NCT00431730` - Is There a Difference in Flicker Induced Vasodilatation Between Smokers and Non-Smokers?	N/A
Not yet recruiting	`NCT05796856` - Effect of Different Wavelengths of Repeated Low-Level Light Therapy on Choroidal and Retinal Blood Flow Among Adults	N/A
Completed	`NCT00431548` - Retinal Oxygen Reactivity in Patients Infected With Human Immunodeficiency Virus (HIV)	N/A