Response to Hyperoxia Clinical Trial
Official title:
Comparing the Effect of Hyperoxic and Conventional Fraction of Inspired Oxygen on Oxidative Stress During Abdominal Surgery.
Verified date | April 2015 |
Source | Istanbul University |
Contact | n/a |
Is FDA regulated | No |
Health authority | Turkey: Ethics Committee |
Study type | Interventional |
Our aim is to compare the effects of 80% and 40% Fraction of inspired oxygen on oxidative stress, antioxidant response (in plasma and bronchoalveolar lavage), extubation quality, preanesthetic and postanesthetic expiration tidal volumes.
Status | Completed |
Enrollment | 40 |
Est. completion date | May 2013 |
Est. primary completion date | May 2013 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 20 Years to 60 Years |
Eligibility |
Inclusion Criteria: - Patients undergoing abdominal surgery, between 20-60 years old, with American Society of Anesthesiology score I or II Exclusion Criteria: - Patients with Chronic Obstructive Pulmonary Disease, Diabetes Mellitus, muscle-bone diseases, inflammatory bowel diseases and patients with malnutrition. Patients will be recruited through general surgery service of our hospital |
Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Prevention
Country | Name | City | State |
---|---|---|---|
Turkey | Cerrahpasa Medical Faculty Anesthesiology and Reanimation Department | Istanbul | Fatih |
Lead Sponsor | Collaborator |
---|---|
Istanbul University |
Turkey,
Koksal GM, Sayilgan C, Aydin S, Uzun H, Oz H. The effects of sevoflurane and desflurane on lipid peroxidation during laparoscopic cholecystectomy. Eur J Anaesthesiol. 2004 Mar;21(3):217-20. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | oxidant and antioxidant response | As primary outcome, the effects of different inspired oxygen fractions on oxidative stress and anti-oxidant response in plasma and bronchoalveolar lavage after intubation and prior to extubation will be evaluated | 4 hours | No |
Secondary | Hemodynamics | The secondary outcome was evaluating the effects of different inspired oxygen fractions on hemodynamics. | 4 hours | No |
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