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Clinical Trial Details — Status: Active, not recruiting

Administrative data

NCT number NCT04528719
Other study ID # mRNA-1345-P101
Secondary ID
Status Active, not recruiting
Phase Phase 1
First received
Last updated
Start date September 30, 2020
Est. completion date June 29, 2024

Study information

Verified date October 2023
Source ModernaTX, Inc.
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The primary objectives of this study are to evaluate the tolerability and reactogenicity of a single injection of up to 5 dose levels of mRNA-1345 in younger adults, women of child-bearing potential, and older adults including Japanese older adults; of 3 injections of the middle dose level of mRNA-1345 given 56 days apart in younger adults; of a booster injection of mRNA-1345 given approximately 12 months after the primary injection in older adults; and of 3 injections of 1 of 2 dose levels of mRNA-1345 given 56 days apart in children who are RSV-seropositive.


Recruitment information / eligibility

Status Active, not recruiting
Enrollment 651
Est. completion date June 29, 2024
Est. primary completion date June 29, 2024
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 12 Months to 79 Years
Eligibility Key Inclusion Criteria: - Healthy young adults =18 to =49 years of age, women of child-bearing potential =18 to =40 years of age, healthy older adults =65 to <80 years of age, Japanese older adults = 60 years of age, and children =12 to < 60 months of age. - Willing and physically able to comply with protocol-mandated follow-up, including all procedures. - Adult participant or parent(s)/legal guardian(s) of pediatric participants has provided written informed consent for participation in this study, including all evaluations and procedures as specified by the protocol. Specific inclusion criteria for adults (younger adults, women of child-bearing potential, and older adults [including Japanese older adults]): - Has a body mass index (BMI) from =18 kilogram (kg)/meter (m)^2 to =35 kg/m^2. - Female participants of non-child-bearing potential. This criterion does not apply for women of child-bearing potential Cohorts 12, 13, and 14. - Female participants of child-bearing potential may be enrolled in the study, if the participant: 1) has a negative urine pregnancy test at Screening and on the day of vaccination; 2) has practiced adequate contraception or has abstained from all activities that could lead to pregnancy for 28 days prior to vaccination; 3) has agreed to continue adequate contraception through 3 months following the last injection; and 4) is not currently breastfeeding. Specific inclusion criteria for children 12 to 59 months of age: - Seropositive for RSV-neutralizing Abs at Screening. - Has received routine immunizations appropriate for age per local guidance. - Current height and weight above the third percentile for age. Specific inclusion criteria for Japanese older adults: - Japanese participants are defined as individuals born in Japan, with both parents and 4 grandparents who were born in Japan. Key Exclusion Criteria: - Has Screening laboratory values Grade =1 (younger adult, women of child-bearing potential, and pediatric participants) or >Grade 1 (older adult participants, including Japanese older adult participants). - Is acutely ill or febrile on the day of the first injection. - Has a significant medical history, including but not limited to: - Congenital or acquired immunodeficiency, including human immunodeficiency virus (HIV) infection. - Chronic hepatitis or suspected active hepatitis. - Bleeding disorder that is considered a contraindication to intramuscular (IM) injection or phlebotomy. - Dermatologic conditions that could affect local solicited AR assessments. - Any history of allergic or anaphylactic reactions following a vaccination that required medical intervention. - Autoimmune disease except for Hashimoto's disease. - Systemic immunosuppressants or immune-modifying drugs for >14 days in total within 6 months prior to the day of enrollment. Topical tacrolimus is allowed if not used within 14 days prior to the day of enrollment. Inhaled, nasal, and topical steroids are allowed. - Intravenous blood products (red cells, platelets, and immunoglobulins [Ig]) within 3 months prior to enrollment. - Has received or plans to receive any licensed or authorized vaccine, to include COVID-19 vaccines, = 28 days prior to the first injection (Day 1) or plans to receive a licensed vaccine within 28 days before or after any study vaccine injection, with the exception of licensed influenza vaccines, which may be received more than 14 days before or after any study vaccine injection. Nonstudy vaccinations should not be delayed. - Has a history of myocarditis, pericarditis, or myopericarditis. Specific exclusion criteria for older adults (Cohorts 7-11 and 15): - Known history of poorly controlled hypertension (per determination of the Investigator) or systolic blood pressure >160 millimeters of mercury (mmHg) at the Screening visit. - Known history of hypotension or systolic blood pressure <85 mmHg at the Screening visit. - Poorly controlled diabetes mellitus (per determination of the Investigator). - Diagnosis of significant chronic pulmonary disease (per determination of the Investigator) (such as, chronic obstructive pulmonary disease, asthma). - Significant chronic cardiovascular disease (per determination of the Investigator). - Resides in a nursing home. - Anticipates the need for immunosuppressive treatment at any time during participation in the study. - Diagnosis of malignancy within previous 10 years (excluding non-melanoma skin cancer and cervical carcinoma in-situ). Specific exclusion criteria for children 12 to 59 months of age (Cohorts 5 and 6): - Has received any monoclonal antibody at any time prior to Screening. - Prior hospitalization for RSV disease in the last 2 years. - Receipt of any prior systemic immunosuppressants or immune-modifying drugs. - Any history of febrile seizures (inclusive of single simple febrile seizure). - History of epilepsy. - History of meningitis.

Study Design


Related Conditions & MeSH terms


Intervention

Biological:
mRNA-1345
Formulation for injection
Drug:
Placebo
0.9% sodium chloride (normal saline) injection

Locations

Country Name City State
United States Velocity Clinical Research (Albuquerque - New Mexico) - PPDS Albuquerque New Mexico
United States Velocity Clinical Research (Binghamton - New York) - PPDS Binghamton New York
United States Velocity Clinical Research - Columbia - PPDS Columbia South Carolina
United States Centricity Research - Roswell - HyperCore - PPDS Columbus Georgia
United States IResearch Atlanta LLC Decatur Georgia
United States Accel Research Site - Angel Kids Pediatrics - ERN - PPDS DeLand Florida
United States Henry Ford Health System Detroit Michigan
United States Velocity Clinical Research (Grand Island - Nebraska) - PPDS Grand Island Nebraska
United States Velocity Clinical Research (Greenville - South Carolina) - PPDS Greenville South Carolina
United States Velocity Clinical Research (Hastings - Nebraska) - PPDS Hastings Nebraska
United States East-West Medical Research Institute Honolulu Hawaii
United States Cyfair Clinical Research Center - ERN - PPDS Houston Texas
United States Alliance for Multispecialty Research - Kansas City Kansas City Missouri
United States Paradigm Clinical Research Institute Inc - ClinEdge - PPDS La Mesa California
United States Velocity Clinical Research (Lafayette - Louisiana) - PPDS Lafayette Louisiana
United States Tanner Clinic Layton Utah
United States Velocity Clinical Research - Medford - ERN - PPDS Medford Oregon
United States Velocity Clinical Research (Metaire - Louisiana) - PPDS Metairie Louisiana
United States Michael W. Simon, M.D., PSC Nicholasville Kentucky
United States Velocity Clinical Research (Norfolk - Nebraska) - PPDS Norfolk Nebraska
United States Velocity Clinical Research (Omaha - Nebraska) - PPDS Omaha Nebraska
United States Accel Research Sites - Nona Pediatric Center - ERN - PPDS Orlando Florida
United States Synexus - Optimal Research - Peoria Peoria Illinois
United States Clinical Research Partners LLC Richmond Virginia
United States Flourish Research - San Antonio - PPDS San Antonio Texas
United States Velocity Clinical Research (Savannah - Georgia) - PPDS Savannah Georgia
United States Velocity Clinical Research (Sioux City - Iowa) - PPDS Sioux City Iowa
United States Velocity Clinical Research (Slidell - Louisiana) - PPDS Slidell Louisiana
United States DM Clinical Research Tomball Texas
United States Mills Clinical Research West Hollywood California
United States Palm Beach Research - ClinEdge - PPDS West Palm Beach Florida

Sponsors (1)

Lead Sponsor Collaborator
ModernaTX, Inc.

Country where clinical trial is conducted

United States, 

Outcome

Type Measure Description Time frame Safety issue
Primary Number of Participants with Solicited Local and Systemic Adverse Reactions (ARs) Up to Day 737 (7 days after each injection)
Primary Number of Participants with Unsolicited Adverse Events (AEs) Up to Day 758 (28 days after the last injection)
Primary Number of Participants with Serious AEs or Medically Attended AEs (MAAEs) Up to Day 1095 (End of Study)
Secondary Geometric Mean Titer (GMT) of Serum RSV Neutralizing and Binding Antibodies (Abs) Up to Day 141 (Cohorts 5 and 6), up to Day 169 (Cohorts 1, 2, 4, 12, 13, 14, and 15), up to Day 281 (Cohort 3), and up to Day 1095 (Cohorts 7, 8, 9, 10, and 11)
Secondary Geometric Mean Fold-Rise of Postbaseline/Baseline Ab Titers Up to Day 141 (Cohorts 5 and 6), up to Day 169 (Cohorts 1, 2, 4, 12, 13, 14, and 15), up to Day 281 (Cohort 3), and up to Day 1095 (Cohorts 7, 8, 9, 10, and 11)
Secondary Proportion of Participants with =2-fold and =4-fold Increases in Ab Titers from Baseline Up to Day 141 (Cohorts 5 and 6), up to Day 169 (Cohorts 1, 2, 4, 12, 13, 14, and 15), up to Day 281 (Cohort 3), and up to Day 1095 (Cohorts 7, 8, 9, 10, and 11)
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