Respiratory Function Clinical Trial
— NPAFOfficial title:
Nanoparticles Emitted by Aircraft Engines, Impact on Respiratory Function
Verified date | March 2017 |
Source | University Hospital, Montpellier |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The goal of this study is to assess the respiratory health of the Air France company's employees working in the Marseilles and Paris airports (flight line and administrative employees). This study was promoted by the Montpellier CHRU, Regional University Hospital Centre (ANSM identification number 2011-A00646-35). It allowes voluntary employees to be involved. They answer a lifestyle survey and perform a spirometry, an exhaled CO measurement and a sampling of exhaled air condensate (EAC). A metrological study of particles emitted by aircraft engines and found in the airport environment will be conducted and the elementary chemical composition analysis, as well a sieve analysis of particles present in the EAC will be conducted.
Status | Completed |
Enrollment | 472 |
Est. completion date | June 2012 |
Est. primary completion date | June 2012 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 65 Years |
Eligibility |
Inclusion Criteria: - Subject must be given free and informed consent and signed the consent - Subject must be affiliated or beneficiary in a health insurance plan Exclusion Criteria: - Subject has a cons-indication (or an incompatible combination therapy) for the realization of the EFR |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Montpellier | Aix Marseille Université, LBM- Nanosecurity platform - CEA Grenoble, LR2N - Nanosecurity platform - CEA Grenoble |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | The quantity of nanoparticules present in exhaled air condensate | The quantity of nanoparticules present in exhaled air condensate | 1 day (Day of inclusion (D0) | |
Secondary | Exhaled CO measurement | Exhaled CO measurement | 1 day (Day of inclusion (D0) | |
Secondary | Exhaled NO measurement | Exhaled NO measurement | 1 day (Day of inclusion (D0) | |
Secondary | Exhaled air condensate | Exhaled air condensate | 1 day (Day of inclusion (D0) | |
Secondary | oxidative stress marker (8 isoprostane) | oxidative stress marker (8 isoprostane) | 1 day (Day of inclusion (D0) | |
Secondary | plasma mass spectrometry which allows the simultaneous assaying of 17 elements | plasma mass spectrometry which allows the simultaneous assaying of 17 elements (Zn, Al, Ti, Co, Cu, Zr, Ni, Cr, Ga, In, Mn, Fe, Se, Cd, Ge, Be) | 1 day (Day of inclusion (D0) | |
Secondary | Lung function | Spirometry value | 1 day (Day of inclusion (D0) |
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