Respiratory Distress Syndrome Clinical Trial
Official title:
Is Synchronization More Effective During Noninvasive Ventilation in Immediately Extubated Preterm Infants?
The purpose of this study is the examination of the hypothesis that synchronized nasal IMV
as compared to non-synchronized nasal IMV will decrease breathing effort in preterm infants
immediately after extubation when recovering from Respiratory distress syndrome (RDS).
Another objective is to examine the effects for synchronized non-invasive mechanical
ventilation on gas exchange and cerebral oxygen saturation.
In this study the investigators plan to test the hypothesis that synchronized nasal IMV
(S-NIMV) as compared to non-synchronized nasal IMV (NIMV) will decrease breathing effort in
preterm infants immediately after extubation when recovery from RDS, as measured by phasic
esophageal pressure deflection.
Furthermore, the investigators plan to evaluate the effects of synchronized NIMV on gas
exchange and brain oxygenation, and to evaluate the reliability of a newly developed
abdominal pressure sensor device for the S-NIMV mode in a newly designed commercially
available ventilator device.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Health Services Research
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