Respiratory Depression Clinical Trial
Official title:
Pupillary Unrest as an Indicator of Central Opioid Effect in Subjects 40-60 Years of Age
This study will establish the relationship between magnitude of opioid exposure and a pupillary measure referred to as PUAL (pupillary unrest in ambient light), in subjects aged 40-60. Previous investigation demonstrated that loss of PUAL was a sensitive, discriminative indicator of opioid toxicity and respiratory depression among subjects aged 20-40 years old. Population data indicate that pupil size and PUAL decline slightly with age. The investigators will explore whether PUAL proves to be a sensitive indicator of opioid exposure and respiratory depression in this older group.
Healthy volunteer subjects aged 40-60 will receive a standardized weight-based 10-minute remifentanil infusion protocol to achieve a peak estimated remifentanil effect site concentration of approximately 6 ng/mL. Pupillary measures will be taken at baseline and regular time intervals during and after the infusion, over a period of 35 minutes. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Active, not recruiting |
NCT03441282 -
Precision Medicine in Anesthesia: Genetic Component in Opioid-induced Respiratory Depression
|
||
Completed |
NCT02907255 -
Vital Sign Monitoring With Continuous Pulse Oximetry and Wireless Clinician Notification After Surgery
|
N/A | |
Completed |
NCT00544947 -
Observation of Respiration Following Regional Anaesthesia With Intrathecal Opioids for Caesarean Section
|
N/A | |
Completed |
NCT02987985 -
Efficacy of Opioid-free Anesthesia in Reducing Postoperative Respiratory Depression in Children Undergoing Tonsillectomy
|
Phase 3 | |
Completed |
NCT02481570 -
Anesthetic Optimization in Scoliosis Surgery
|
N/A | |
Completed |
NCT06083272 -
VitalThings Guardian Contactless Monitoring
|
||
Not yet recruiting |
NCT06064409 -
Optimal Timing and Failure Prediction of High Flow Nasal Cannula Oxygen Therapy in Emergency Department: Prospective Observational Single Center Study
|
||
Completed |
NCT00345384 -
Dexmedetomidine for the Control of Post-Operative Pain in Thoracotomy Patients
|
Phase 1/Phase 2 | |
Recruiting |
NCT04046068 -
Multimodal Perioperative Pain Management: ComfortSafe Program
|
||
Recruiting |
NCT02819661 -
Respiratory Depression in Women With BMI≥30 Underwent Spinal Anesthesia With Intrathecal Morphine in Elective C-section
|
N/A | |
Active, not recruiting |
NCT04011163 -
Vital Signs-Integrated Patient-Assisted Intravenous Opioid Analgesia for Post Surgical Pain
|
Phase 2/Phase 3 | |
Active, not recruiting |
NCT06374589 -
Closed-Loop O2 Use During High Flow Oxygen Treatment Of Critical Care Adult Patients (CLOUDHFOT)
|
N/A | |
Terminated |
NCT02760927 -
Assessment of a Oral Endotracheal Tube Fastener on Patients Intubated With Oral Endotracheal Tubes
|
N/A | |
Completed |
NCT01869582 -
Safer Births - Reducing Perinatal Mortality
|
N/A | |
Completed |
NCT00875134 -
Testing of the Apnea Prevention Device
|
Phase 1/Phase 2 | |
Not yet recruiting |
NCT06137638 -
ENA-001 for Post Operative Respiratory Depression (PORD)
|
Phase 2 | |
Completed |
NCT01843933 -
Detecting Post-Operative Respiratory Depression in Children
|
N/A | |
Completed |
NCT00696137 -
Long-term Extension Study of BEMA™ Fentanyl
|
Phase 3 | |
Completed |
NCT04017702 -
Detection of Postoperative Respiratory Depression in High Risk Patients Utilizing Minute Ventilation Monitoring
|
||
Withdrawn |
NCT04495452 -
Precision Medicine in Anesthesia
|