A Cluster Randomized Trial to Improve Weaning and Extubation From Mechanical Ventilation in Community Hospitals

Respiration, Artificial Clinical Trial

Official title:

A Cluster Randomized Trial to Improve Weaning and Extubation From Mechanical Ventilation in Community Hospitals

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00157287
• Other study ID #: R-01-076
• Status: Completed
• Phase: Phase 3
• First received: September 8, 2005
• Last updated: August 24, 2017
• Start date: June 2003
• Est. completion date: April 2006

Study information

• Verified date: August 2017
• Source: Lawson Health Research Institute
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Protocol directed weaning has been shown to reduce the duration of mechanical ventilation for patients admitted to the intensive care unit (ICU) of tertiary centres. However, this benefit has not previously been studied in a community hospital setting. We therefore sought to evaluate the impact of an evidence-based weaning guideline on the outcomes for patients receiving mechanical ventilation in the ICUs of community hospitals in a cluster randomized controlled trial involving 11 community hospitals.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 0
• Est. completion date: April 2006
• Est. primary completion date: June 2005
• Accepts healthy volunteers: No
• Gender: All
• Age group: 16 Years and older

Eligibility

Inclusion Criteria:

• patients ventilated for more than 24 hours

Exclusion Criteria:

• patients less than 16 years of age patients who receive only non-invasive ventilation patients chronically ventilated at time of ICU admission patients who will not be candidates for weaning from ventilation at time of admission If withdrawl of life support is imminent at the point the patient has been ventilated for 24 hours

Related Conditions & MeSH terms

• Respiration, Artificial

Intervention

Procedure:
• Evidence based weaning protocol

Locations

Country	Name	City	State
Canada	William Osler Health Centre (Brampton)	Brampton	Ontario
Canada	Brant Community Health Systems	Brantford	Ontario
Canada	Joseph Brant Memorial Hospital	Burlington	Ontario
Canada	Guelph General Hospital	Guelph	Ontario
Canada	St. Joseph's Health Care	London	Ontario
Canada	Trillium Health Centre	Mississauga	Ontario
Canada	North Bay General Hospital	North Bay	Ontario
Canada	Lakeridge Health Corporation (Oshawa)	Oshawa	Ontario
Canada	Stratford General Hospital	Stratford	Ontario
Canada	St. Joseph's Health Centre	Toronto	Ontario
Canada	Hotel Dieu of St. Joseph	Windsor	Ontario

Sponsors (1)

Lead Sponsor	Collaborator
Lawson Health Research Institute

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	ICU length of stay
Secondary	duration of ventilation
Secondary	length of hospital stay
Secondary	complications (re-intubation within 48 hours, pneumonia within 48 hours)
Secondary	ICU mortality
Secondary	Hospital mortality
Secondary	ICU readmissions
Secondary	Qulaity of life