Clinical Trials Logo

Clinical Trial Summary

Background: Aging is associated with muscle mass and strength loss and "oldest" old people (≥85 y) are at a far greater risk of developing sarcopenia. Training increases muscle mass and strength in a variety of populations, yet the efficacy has not been clearly defined for individuals in the fourth age (≥80 y). Hypothesis: The following hypotheses will be investigated: - Twelve weeks of progressive resistance-type exercise training increases muscle mass and strength in young old (65-75 y) and oldest old (85 y and over) subjects. - The training-induced increase in muscle mass and strength is relatively greater in young old subjects when compared to oldest old subjects. Goals: The primary aim of this study is to compare the effect of resistance-type exercise training on skeletal muscle mass (i.e. quadriceps cross-sectional area and whole body lean mass) in young old and oldest old subjects. Specific goals - Determine whether resistance-type exercise training can increase muscle mass and muscle strength in young old and oldest old subjects. - Determine whether resistance-type exercise training can improve physical performance in young old and oldest old subjects. - Identify whether inflammatory markers (i.e., TNFα, IL-4, IL-6, IL-10, IL-13) are up- or down-regulated in young old and oldest old subjects before and after resistance-type exercise training. Methodology: Study design Sixty older females and males (young old group: n=30, 65-75 y; oldest old group: n=30, 85 y and over) will be included in this prospective clinical trial. All volunteers will be subjected to 12 weeks of whole-body resistance-type exercise training (3x/wk). Before, and after 6 and 12 weeks of training, a computed tomography (CT) scan of the upper leg will be performed to assess quadriceps cross sectional area. On those days, fasting blood samples will be obtained and whole-body dual energy x-ray absorptiometry (DEXA) scan will also be performed. Maximal strength will be determined by 1-repetition maximum (1RM) and physical functioning by the short physical performance battery (SPPB) at the same time points.


Clinical Trial Description

Background: Aging is associated with muscle mass and strength loss and "oldest" old people (≥85 y) are at a far greater risk of developing sarcopenia. Training increases muscle mass and strength in a variety of populations, yet the efficacy has not been clearly defined for individuals in the fourth age (≥80 y). A better understanding of the skeletal muscle adaptive response to resistance-type exercise training with advanced age will provide a strong basis to develop and implement care programs within our rapidly aging population, in which the "oldest" old represent the fastest growing group. Hypothesis: The following hypotheses will be investigated: - Twelve weeks of progressive resistance-type exercise training increases muscle mass and strength in young old (65-75 y) and oldest old (85 y and over) subjects. - The training-induced increase in muscle mass and strength is relatively greater in young old subjects when compared to oldest old subjects. Goals: The primary aim of this study is to compare the effect of resistance-type exercise training on skeletal muscle mass (i.e. quadriceps cross-sectional area and whole body lean mass) in young old and oldest old subjects. Specific goals - Determine whether resistance-type exercise training can increase muscle mass and muscle strength in young old and oldest old subjects. - Determine whether resistance-type exercise training can improve physical performance in young old and oldest old subjects. - Identify whether inflammatory markers (i.e., TNFα, IL-4, IL-6, IL-10, IL-13) are up- or down-regulated in young old and oldest old subjects before and after resistance-type exercise training. Methodology: Study design Sixty older females and males (young old group: n=30, 65-75 y; oldest old group: n=30, 85 y and over) will be included in this prospective clinical trial. All volunteers will be subjected to 12 weeks of whole-body resistance-type exercise training (3x/wk). Before, and after 6 and 12 weeks of training, a computed tomography (CT) scan of the upper leg will be performed to assess quadriceps cross sectional area. On those days, fasting blood samples will be obtained and whole-body dual energy x-ray absorptiometry (DEXA) scan will also be performed. Maximal strength will be determined by 1-repetition maximum (1RM) and physical functioning by the short physical performance battery (SPPB) at the same time points. Study parameters/endpoints - The main study endpoint is the increase in quadriceps cross-sectional area as assessed via CT scan. - Secondary endpoints include: Whole-body and segmental body composition (i.e., lean mass, fat mass, bone mineral content; DEXA scan); Maximal strength assessment (1RM); Hand grip strength; Short physical performance battery (SPPB); Inflammatory and molecular markers (blood samples analysis). - Other study parameters include: Age, body weight, body height, body mass index (BMI), lipid profile, glucose, and insulin. Expected results: The impact of resistance-type exercise training to increase muscle mass and strength in the oldest old population remains unclear. With the proposed project, we expect that resistance-type exercise training will increase muscle mass and strength, although the impact will be relatively lower in the oldest old group when compared with a group of young old individuals. The potential findings will define the efficacy of resistance-type exercise training to increase muscle mass and strength in individuals with advancing age. Better maintenance, or even an increase in muscle mass and strength increases independence, prolonging good health, recovery from disease and illness, and ultimately decreases burden on healthcare systems. This information will have a beneficial impact in the exercise physiology and aging areas for future interventions at the local, regional, national and international levels. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04999501
Study type Interventional
Source Universidad de La Frontera
Contact
Status Completed
Phase N/A
Start date June 10, 2018
Completion date October 30, 2022

See also
  Status Clinical Trial Phase
Completed NCT05987046 - Contrast Training, Post-activation Countermovement Jump Performance in High Strength Male N/A
Completed NCT04136821 - The Long-term Effects of Oceanix™ on Resistance Training Adaptations N/A
Recruiting NCT05945641 - Effect of Low-load Resistance Training vs. High-intensity Interval Training on Local Muscle Endurance N/A
Completed NCT04069351 - Body Composition Changes During Overfeeding Plus Resistance Training N/A
Not yet recruiting NCT06360536 - Remotely Delivered Resistance Training for Cardiometabolic Health Among Black Women N/A
Completed NCT04535596 - Blood Flow Restriction Exercises and Conservative Exercises in Knee Osteoarthritis N/A
Completed NCT04213586 - Effects of Whey Protein and Collagen Supplementation N/A
Completed NCT05052164 - Improvement Of Physical And Physiological Parameters In Menopausal Or Post-Menopausal Celiac Women N/A
Completed NCT04630951 - Blood Flow Restriction Strength Training in Professional Soccer Players N/A
Not yet recruiting NCT03722277 - Variable Resistance Training in Patients With Osteoarthrosis of the Knee N/A
Completed NCT00991523 - Overnight Post-Exercise Recovery After Protein Ingestion Prior to Sleep N/A
Completed NCT01216722 - Study of Resistance Strengthening Versus Ambulation Post-Liver Transplant N/A
Recruiting NCT06131047 - High Intensity Resistance Training With and Without Blood Flow Restriction in ACL Reconstruction N/A
Recruiting NCT06131138 - Aquatic Exercises VS Core Strengthening on Disability, Flexibility and Postural Stability in Weightlifters. N/A
Recruiting NCT06131125 - Plyometric vs Explosive Strength Training on Agility, Power, and Balance in Basketball Players N/A
Recruiting NCT06240962 - Mindfulness Practice vs Strength Training on Pain, Kinesiophobia and Function Among Sprinters N/A
Completed NCT04315077 - The Short Term Effects of Oceanix Supplementation on Recovery N/A
Completed NCT05597423 - Massage as Recovery Strategy After Resistance Training N/A
Completed NCT02327975 - Prescription of Physical Exercise Through Mobile Application in Elderly N/A
Active, not recruiting NCT06171841 - Effects of Low-Intensity Blood Flow Restriction Training in Normoxia and Hypoxia Conditions N/A