Effect of Calcium Chloride on Recovery From Neuromuscular Blockade

Status Completed

Clinical Trial Summary

The purpose of this study is to evaluate the effect of calcium chloride against residual neuromuscular blockade at the end of general anesthesia

Clinical Trial Description

During general anesthesia, neuromuscular blocking agent is administered to facilitate endotracheal intubation and the view of operative field. The neuromuscular blockade should be reversed at the end of anesthesia to recover spontaneous breathing of the patient.

Residual neuromuscular blockade (RNMB) is defined as train of-four ratio < 0.9. RNMB is a risk factor for postoperative pulmonary complication and increases postoperative mortality. Neostigmine is acetylcholinesterase inhibitor routinely used at the end of anesthesia to prevent RNMB. A meta-analysis, however, showed that 40 percent of patients who received intermediate-acting neuromuscular blocking agent during anesthesia showed RNMB in PACU.

Calcium triggers the release of acetylcholine from the motor nerve terminal and enhances excitation-contraction coupling in muscle. Increasing calcium concentrations decreased the sensitivity to dTc and pancuronium in an animal muscle-nerve model. The effect of calcium chloride on residual neuromuscular blockade is not studied yet.

The purpose of this study is to evaluate the effect of calcium chloride on residual neuromuscular blockade at the end of general anesthesia ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Prevention

Related Conditions & MeSH terms

Residual Neuromuscular Blockade

Clinical Trial Details

NCT number	NCT02213848
Study type	Interventional
Source	Seoul National University Hospital
Contact
Status	Completed
Phase	N/A
Start date	August 2014
Completion date	October 2014

View Details

See also
Status	Clinical Trial	Phase
Enrolling by invitation	`NCT04619225` - Cardiac Output and Recovery Time	N/A
Recruiting	`NCT05992090` - Neuromuscular Blockade Monitoring Using Kine-myography vs Electromyography.
Completed	`NCT02146859` - Predictor of Residual Neuromuscular Blockade in Recovery Room After General Anesthesia
Completed	`NCT03585400` - Validation of the REPS Prediction Tool
Terminated	`NCT01678625` - Electromyographic Assessment of Onset and Recovery of Neuromuscular Blockade
Completed	`NCT03417804` - Incidence of Postoperative Residual Neuromuscular Blockade in Portugal
Completed	`NCT03111082` - Incidence of Postoperative Neuromuscular Blockade in Post-Anesthesia Care Unit at Parkland Hospital: Does Size Matter?
Completed	`NCT04244266` - Observational Study in Bariatric Surgery
Completed	`NCT02939911` - Residual Neuromuscular Blockade in Pediatric Anesthesia
Completed	`NCT02660398` - Incidence and Severity of Residual Neuromuscular Blockade	Phase 4
Completed	`NCT03920670` - Comparison of the ToFscan and TetraGraph During Recovery of Neuromuscular Function in the Post Anesthesia Care Unit	N/A
Completed	`NCT01837498` - Reversal of Neuromuscular Blockade in Thoracic Surgical Patients
Completed	`NCT04312256` - Thumb vs Great Toe Recovery	N/A
Completed	`NCT04352127` - Visual and Electromyography Assessments in Response to Train-of-Four Stimulation of the Ulnar Nerve	N/A
Completed	`NCT04352140` - Electromyographic and Acceleromyographic Monitoring in Restricted Arm Movement Surgical Setting	N/A
Withdrawn	`NCT03574337` - Residual Neuromuscular Blockade in Cardiac Surgery Patients	Phase 4