Myocardial and Renal Dysfunction by Oxidative Stress Caused by Cardiac Surgery

Reperfusion Injury Clinical Trial

Official title:

Myocardial and Renal Dysfunction by Oxidative Stress Caused by Cardiac Surgery

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT02394405
• Other study ID #: OD-CABG-2015
• Status: Terminated
• Start date: March 2015
• Est. completion date: December 2018

Study information

• Verified date: August 2019
• Source: Moscow Regional Research and Clinical Institute Moniki n.a. M.F. Vladimirskiy
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Assessment of the severity of oxidative stress caused by the on-pump and off-pump cardiac surgery using mtDNA, nDNA, carbonilated proteins, nitrotyrosine, oxy-LDL, S100b-protein.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 21
• Est. completion date: December 2018
• Est. primary completion date: March 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria:

• shedduled CABG

Exclusion Criteria:

• stroke befor surgery

• miocardial infarction 6 monthes befor surgery

• dementia

• liver cirrhosis

Related Conditions & MeSH terms

• Renal Insufficiency
• Reperfusion Injury

Locations

Country	Name	City	State
Russian Federation	Moscow Regional Research and Clinical Institute Moniki n.a. M.F. Vladimirskiy	Moscow

Sponsors (1)

Lead Sponsor	Collaborator
Moscow Regional Research and Clinical Institute Moniki n.a. M.F. Vladimirskiy

Country where clinical trial is conducted

Russian Federation, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Assay of mtDNA		from baseline whithin 72 hours
Secondary	Assay of nDNA		from baseline whithin 72 hours
Secondary	Assay of carbonilated proteins		from baseline whithin 72 hours
Secondary	Assay of nitrotyrosine		from baseline whithin 72 hours
Secondary	Assay of oxy-LDL		from baseline whithin 72 hours
Secondary	Assay of S100b-protein		from baseline whithin 72 hours