Renal Tubular Transport Clinical Trial
Official title:
The Effect of Acyl-Ghrelin on Kidney Function and Blood Pressure in Healthy Volunteers - A Randomized, Cross-over, Single-blind, Placebo-controlled Dose-response Study of the Acyl-ghrelin Induced Effects on GFR, Tubular Transport of Sodium and Water in Different Nephron Segments and Central and Peripheral Blood Pressure
Ghrelin (growth hormone release inducer) is produced in the stomach. The active form of
Ghrelin is Acyl-Ghrelin. Acyl-Ghrelin stimulates the Ghrelin receptors. Ghrelin receptors
are detected in the distal tubules in mice and animal studies have shown that Ghrelin
increases the absorption of sodium in the renal tubules. Ghrelin infusion directly into the
renal artery of rats increased sodium reabsorption in the distal nephron, presumably via the
epithelial sodium channels (ENaC).
The purpose of the study is to measure the acyl-ghrelin induced effects on GFR, tubular
transport of sodium and water in different nephron segments and central and peripheral blood
pressure in a randomized, cross-over, single-blind, placebo-controlled dose-response study.
n/a
Allocation: Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Basic Science