Renal Transplantation Clinical Trial
Official title:
Cross-sectional Analysis of Subclinical Interstitial Lung Abnormalities in Stable Renal Transplant Recipients by High-resolution CT Scan
Immunosuppressive drugs such as tacrolimus, cyclosporine, mycophenolate mofetil, sirolimus and everolimus may have toxic pulmonary effects, particularly interstitial alterations. The aim of the present study is to explore the presence of subclinical interstitial lung abnormalities in stable renal transplant recipients taking the different immunosuppressive drugs used as maintenance therapy for renal transplantation.
Prospective, cross-sectional study examining the high-resolution CT scans obtained in 63
stable renal transplant recipients taking immunosuppressive treatment for at least 24
months. The findings in patients taking the newer immunosuppressive drugs (mycophenolic
acid, sirolimus and everolimus) are compared with those of the patients treated in the
traditional way (cyclosporine, tacrolimus, azathioprine). All patients undergo
high-resolution CT scanning.
Eligibility criteria: recipients of kidney or kidney-pancreas transplant, on
immunosuppressive therapy for at least 24 months, with stable renal function and absence of
any overt lung disease or lung alterations induced by other drugs, systemic diseases or
occupational exposure to fibrogenic agents.
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Observational Model: Cohort, Time Perspective: Prospective
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