Renal Transplantation Clinical Trial
Official title:
The Effect of Simvastatin on Desensitization of Panel-Positive Kidney Transplant Candidates
Patients with panel reactive antibodies have many difficulties to find a crossmatch-negative kidney for transplantation and are at the risk of post transplantation rejection more than other transplanted patients. We evaluated the effect of simvastatin on PRA and post transplant outcome of these sensitized patients. We also performed a descriptive study.
The presence of panel reactive antibodies (PRAs) in the sera of renal transplant candidates
is associated with hyperacute or delayed humoral immune responses against the graft after
transplantation .
In addition, these sensitized patients wait for a long time to find a cross-match negative
kidney for renal transplantation . As a result, some modalities have been used for
desensitization including plasmapheresis and intravenous immunoglobulin (IVIG) in
combination with immunosuppressive drugs .
However, recently, the use of statins such as simvastatin, pravastatin and etc. has been
proposed to be safer and more effective for desensitization .
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Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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