Renal Insufficiency Clinical Trial
Official title:
Phase IV Multi Center Validation Study of Novel Biomarkers of Acute Kidney Injury After Cardiac Surgery
People who undergo coronary artery bypass grafting (CABG) or heart valve surgery may experience acute kidney injury (AKI) after their surgery. Current medical tests cannot identify AKI until approximately 48 hours after it occurs. This study will examine three new biomarkers in blood and urine that may provide a more effective and faster way of predicting AKI in people who undergo CABG or heart valve surgery.
AKI, which is indicated by a sudden change in serum creatinine levels, is a serious
complication that can occur after a patient undergoes CABG or heart valve surgery. People who
experience AKI after heart surgery may be at increased risk for post-operative complications,
including long-term kidney failure or heart damage. AKI is currently identified by testing
serum creatinine levels in the blood, which is the traditional marker of kidney function.
However, serum creatinine levels can be affected by other non-kidney-related factors and may
not positively identify AKI until 48 hours after it begins. This study will examine three new
biomarkers found in urine and blood—urine interleukin 18 (IL-18), neutrophil
gelatinase-associated lipocalin (NGAL), and cystatin C—that may be able to predict AKI more
effectively and faster than serum creatinine levels. In addition, study researchers will also
determine if changes in these biomarkers can predict the severity of AKI more successfully
than serum creatinine tests.
This study will enroll people undergoing CABG or heart valve surgery at Yale-New Haven
Hospital. Before the surgery and once a day for 5 days after the surgery, blood and urine
collection will occur. Study researchers will also review participants' medical records.
Twelve months after hospital discharge, participants will return to the clinic for a
follow-up visit for repeat blood and urine collection and to complete questionnaires. A
portion of blood will be saved for future genetic testing; this is optional.
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