Renal Failure Clinical Trial
Official title:
EPO to Protect Renal Function After Cardiac Surgery. A Phase II Double Blind Randomized Controlled Study.
The purpose of this study is to evaluate the potential of erythropoietin in reducing risk and degree of acute kidney injury after cardiac surgery.
Acute kidney injury is a common complication after cardiac surgery and is associated with
decreased long-term survival.
Several experimental and animal studies have showed cytoprotective, preconditioning and
anti-apoptotic effects of high dose erythropoietin. Clinical studies in human have also
suggested that high dose erythropoietin has preconditioning effects against injury after
ischemia and reperfusion on different organs in human, such as brain, heart, liver, and
kidneys.
Administration of Epo in high doses in conjunction with cardiac surgery has shown to be safe
with no direct side-effects.
The investigators therefore hypothesize that a preconditioning effect of erythropoietin
before cardiac surgery can reduce the level of renal dysfunction after surgery in a group
with preoperative renal impairment.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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