Assessment of Circulating Copeptin Levels in Healthy Subjects and Patients With Renal Insufficiency After Oral Water Load and Hypertonic Saline Infusion

Renal Failure Clinical Trial

Official title:

Assessment of Circulating Copeptin Levels in Healthy Subjects and Patients With Renal Insufficiency After Oral Water Load and Hypertonic Saline Infusion

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00696605
• Other study ID #: Swiss AVP-Copeptin Trial
• Status: Completed
• Phase: N/A
• First received: June 10, 2008
• Last updated: February 23, 2017
• Start date: July 2008
• Est. completion date: October 2009

Study information

• Verified date: February 2017
• Source: Hospital Centre Biel/Bienne
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The are 2 principal goals in this study:

1. To measure plasma copeptin levels in healthy subjects and to correlate them with plasma AVP concentrations and urine osmolalities in iso-, hypo-, and hyperosmolar states.

2. To measure plasma copeptin concentrations in patients with chronic renal failure under the same conditions described above, in order to characterize the impact of renal function on circulating copeptin levels in correlation to plasma AVP and urine osmolality.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 20
• Est. completion date: October 2009
• Est. primary completion date: January 2009
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• chronic renal failure grade I through IV

• healthy age-matched controls

Exclusion Criteria:

• chronic renal failure grade V

• heart failure

• liver disease

• nephrotic syndrome

• anemia (hemoglobin level < 100 g/L)

• uncontrolled hypertension (systolic BP > 160 mmHg; diastolic BP > 95 mm Hg)

• coexisting severe disease

• known thyroid disease

• known hypocortisolism

• known hypercortisolism

• known diabetes insipidus

• pregnancy

• lactation

Related Conditions & MeSH terms

• Hyperosmolality
• Hypoosmolality
• Renal Failure
• Renal Insufficiency

Locations

Country	Name	City	State
Switzerland	Clinic of Internal Medicine, Hospital Center	Biel/Bienne

Sponsors (2)

Lead Sponsor	Collaborator
Hospital Centre Biel/Bienne	Brahms AG

Country where clinical trial is conducted

Switzerland,