Renal Dialysis Clinical Trial
Official title:
Effects of L-carnitine Therapy on the Heart of Maintenance Hemodialysis Patients: A Multicenter, Prospective, Non-randomized, Controlled Real-world Study
This study is intended to be a multicenter, prospective, non-randomized, controlled real-world study. Patients receiving L-carnitine injection were included in the experimental group and the control group according to whether they received L-carnitine injection. Patients receiving L-carnitine injection were included in the experimental group, and those receiving L-carnitine injection were included in the control group.To observe the effects of L-carnitine on cardiac function in hemodialysis patients.
Status | Not yet recruiting |
Enrollment | 1000 |
Est. completion date | June 30, 2023 |
Est. primary completion date | June 30, 2023 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 80 Years |
Eligibility | Inclusion Criteria: - Maintenance hemodialysis patients; - 18 years<80 years; - Have clear consciousness and independent behavior ability; - Before dialysis, the total carnitine concentration was less than 40 umol/L, or the free carnitine concentration was less than 35 umol/L. Exclusion Criteria: - Acute cardiovascular and cerebrovascular diseases occurred within 1 month; - Infectious diseases occurred within 1 month; Treatment with glucocorticoid or immunosuppressant; - Patients who have used L-carnitine within 2 weeks. - Hematological system tumor or tumor; |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
The First Affiliated Hospital of Zhejiang Chinese Medical University |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change from baseline in Left ventricular ejection fraction | baseline and week 12 | ||
Secondary | Change from baseline in Brain natriuretic peptide level | baseline ,week 4 and week 12 | ||
Secondary | Change from baseline in left ventricular short axis shortening rate | baseline and week 12 | ||
Secondary | Change from baseline in stroke volume | baseline and week 12 | ||
Secondary | Change from baseline in the ratio of peak E to peak A of mitral valve blood flow velocity in early and late diastolic periods | baseline and week 12 | ||
Secondary | Change from baseline in serum albumin | baseline and week 12 | ||
Secondary | Change from baseline in upper arm circumference | baseline and week 12 | ||
Secondary | Change from baseline in prealbumin | baseline and week 12 | ||
Secondary | Change from baseline in hemoglobin | baseline and week 12 |
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