A Drug-Drug Interaction Study of the Effects of XL184 (Cabozantinib) on Rosiglitazone in Subjects With Solid Tumors

Renal Cell Carcinoma Clinical Trial

Official title:

A Phase 1 Drug-Drug Interaction Study of the Effects of XL184 on the Pharmacokinetics of a Single Oral Dose of Rosiglitazone in Subjects With Solid Tumors

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01100619
• Other study ID #: XL184-008
• Status: Completed
• Phase: Phase 1
• First received: March 22, 2010
• Last updated: September 17, 2013
• Start date: April 2010

Study information

• Verified date: September 2013
• Source: Exelixis
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Food and Drug Administration
• Study type: Interventional

Clinical Trial Summary

The primary objective of this clinical study is to determine whether the inhibition of cytochrome P450 (CYP) isozyme CYP2C8 by XL184 observed in in vitro preclinical studies translates into the potential for clinically significant drug-drug interactions in humans. The study will measure the effect of once daily dosing of XL184 on the pharmacokinetics (PK) of rosiglitazone. The PK of XL184 when combined with rosiglitazone will be evaluated as well.

A specific objective of this study is to determine whether the interaction between XL184 and a drug such as rosiglitazone is sufficiently large enough to necessitate a dosage adjustment when used in combination with XL184, or whether the interaction would require additional therapeutic monitoring.

Rosiglitazone, commonly known as Avandia, is a prescription medicine approved by the FDA used to treat adults with Type 2 (adult-onset or non-insulin dependent) diabetes mellitus (high blood sugar). In this study, subjects will only take 2 doses of rosiglitazone. There is no intention of therapy as a result of taking rosiglitazone in this study.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 40
• Est. primary completion date: August 2012
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Diagnosis of a solid tumor that is metastatic or unresectable and is refractory to or progressed (or relapsed) following standard therapies, or a disease for which no standard therapy exists. Initial enrollment will be limited to differentiated thyroid cancer and renal cell carcinoma. Additional criteria will apply.

• One lesion that is not within a previously radiated field and is measurable on computerized tomography (CT), magnetic resonance imaging (MRI) scan.

• Body mass index (BMI) between 18 and 33 kg/m2.

• Karnofsky Performance Status (= 70).

• Adequate organ and marrow function.

• Able to reside in the clinic for two one-day confinement periods in their entirety.

• The subject is willing to refrain from consuming CYP-interacting foods including Seville orange-containing products, grapefruit-containing products, and star fruit-containing products, from 72 hours prior to first dose through the Day 23 Discharge.

Exclusion Criteria:

• Restrictions regarding certain prior treatments will apply.

• The subject has experienced clinically-significant hematemesis or hemoptysis of > 2.5 ml of red blood within 28 days prior to the first dose of study treatment, or other signs indicative of pulmonary hemorrhage within 28 days prior to the first dose of study treatment.

• Not recovered from toxicity due to all prior therapies (ie, return to pre-therapy baseline or Grade = 1).

• Primary brain tumor or brain metastases or spinal cord compression, unless completed radiation therapy = 28 days prior to study. treatment or had surgical resection and is stable without steroid and without anti-convulsant treatment for = 10 days.

• Prothrombin time/International Normalized Ratio (PT/INR) or partial thromboplastin time (PTT) at screening = 1.5 times the laboratory upper limit of normal.

• Uncontrolled, significant intercurrent illness.

• Inherited bleeding diathesis or coagulopathy with the risk of bleeding.

• Pregnancy or breastfeeding.

• Human immunodeficiency virus (HIV), Hepatitis B, or Hepatitis C.

• Allergy or hypersensitivity to components of either of the study treatment (XL184 and rosiglitazone) formulations.

• History of any medical or surgical conditions (eg, stomach or intestinal surgery or resection) that would potentially interfere with or alter the gastrointestinal (GI) absorption, distribution, metabolism, or excretion of the study drug (exceptions: appendectomy, hernia repair, and/or cholecystectomy will be allowed).

• History of, or clinical evidence of, pancreatic injury or pancreatitis, including but not limited to having amylase or lipase levels outside of normal limits.

• Hepatic impaired, ie, with a Child-Pugh score of B or C.

• The subject is being treated with drug(s) that are known to be either extensively metabolized by CYP2C8 (for example rosiglitazone), or inhibitors of either CYP2C8 or CYP3A4, or inducers of CYP3A isozymes.

• The subject has used any prohibited prescription medications or products prior to the first Check-in, or is unable or unwilling to forgo the use of such products from the first Check-in through the Day 23 Discharge, unless deemed acceptable by the investigator.

• Poor peripheral venous access.

• The subject is receiving warfarin (or other coumarin derivatives) at study entry and unable to switch to low molecular weight heparin.

• The subject is receiving dialysis.

Study Design

Endpoint Classification: Pharmacokinetics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Carcinoma
• Carcinoma, Renal Cell
• Follicular Thyroid Cancer
• Huerthle Cell Thyroid Cancer
• Papillary Thyroid Cancer
• Renal Cell Carcinoma
• Thyroid Diseases
• Thyroid Neoplasms

Intervention

Drug:
• rosiglitazone
one 4 mg dose as a tablet followed by a second 4 mg dose 3 weeks later
• XL184
dosed with capsules daily

Locations

Country	Name	City	State
United States	Dana Farber Cancer Institute	Boston	Massachusetts
United States	Montefiore Medical Center	Bronx	New York
United States	City of Hope Comprehensive Cancer Center	Duarte	California
United States	The University of Texas M.D. Anderson Cancer Center	Houston	Texas
United States	Hospital of the University of Pennsylvania	Philadelphia	Pennsylvania

Sponsors (1)

Lead Sponsor	Collaborator
Exelixis

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Pharmacokinetics of XL184 and rosiglitazone	To evaluate the effect of multiple daily doses of XL184 on single dose PK of rosiglitazone	at weekly or twice-weekly visits for the first 4 weeks	No
Secondary	Safety and tolerability of repeated administration of XL184	To evaluate safety and tolerability of daily oral administration of XL184 and two single doses of rosiglitazone	at weekly or twice-weekly visits, then every 4 weeks	Yes
Secondary	Pharmacokinetics of XL184 after co-administration of rosiglitazone	To evaluate the plasma PK of XL184 after a single dose of rosiglitazone	at weekly or twice-weekly visits for 4 weeks	No