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Clinical Trial Summary

The primary objective of the study is to evaluate the feasibility of 89Zr-bevacizumab PET imaging as a biomarker before and during treatment with sunitinib or bevacizumab plus interferon in patients with RCC. 89Zr-bevacizumab PET imaging will be regarded a promising biomarker if the target for treatment (VEGF) can be visualised and if uptake changes after institution of treatment.


Clinical Trial Description

- To explore if 89Zr-bevacizumab PET imaging can differentiate RCC patients with progressive disease from patients with non-progressive disease during treatment with sunitinib or bevacizumab plus interferon. - To explore relationships between VEGF pathway related biomarkers and 89Zr-bevacizumab PET response. - To explore effect of 2 weeks off treatment in the sunitinib arm on pharmacodynamic biomarkers and 89Zr-bevacizumab PET response. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT00831857
Study type Observational
Source University Medical Center Groningen
Contact
Status Completed
Phase
Start date January 2009
Completion date September 2011

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