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Clinical Trial Summary

This is a single arm, phase II trial of HLA-haploidentical related hematopoietic cells transplant (Haplo-HCT) using reduced intensity conditioning (fludarabine and melphalan and total body irradiation). Peripheral blood is the donor graft source. This study is designed to estimate disease-free survival (DFS) at 18 months post-transplant.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms

  • Acute Lymphoblastic Leukemia
  • Acute Myeloid Leukemia
  • Biphenotypic Acute Leukemia
  • Burkitt Lymphoma
  • Chronic Myelogenous Leukemia
  • Hematologic Neoplasms
  • Hodgkin Lymphoma
  • Leukemia
  • Leukemia, Biphenotypic, Acute
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive
  • Leukemia, Myeloid
  • Leukemia, Prolymphocytic
  • Lymphoma
  • Lymphoma, Mantle-Cell
  • Lymphoplasmacytic Lymphoma
  • Mantle Cell Lymphoma
  • Myelodysplastic Syndromes
  • Myeloproliferative Disorders
  • Myeloproliferative Neoplasm
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Prolymphocytic Leukemia
  • Relapsed Chronic Lymphocytic Leukemia
  • Relapsed Follicular Lymphoma
  • Relapsed Large Cell Lymphoma
  • Relapsed Marginal B-cell Lymphoma
  • Relapsed Small Lymphocytic Lymphoma
  • Relapsed T-Cell Lymphoma
  • Undifferentiated Leukemia
  • Waldenstrom Macroglobulinemia

NCT number NCT04191187
Study type Interventional
Source H. Lee Moffitt Cancer Center and Research Institute
Contact
Status Active, not recruiting
Phase Phase 2
Start date December 6, 2019
Completion date February 2025

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