Regional Blood Flow Clinical Trial
Official title:
Effects of Vitamin C on Hyperoxia-Induced Reduction of Retinal Blood Flow
High arterial blood oxygen tension leads to vasoconstriction of retinal vessels, possibly
related to an interaction between reactive oxygen species and endothelium-derived vasoactive
factors. Vitamin C is a potent antioxidant capable of reversing endothelial dysfunction due
to increased oxidant stress. Vitamin C appears to have vasodilatory properties, but the
underlying mechanisms are not well understood.
In the present study we hypothesized that hyperoxic vasoconstriction of retinal vessels
could be diminished by vitamin C.
Ocular blood flow will be determined by non-invasive methods, including laser Doppler
velocimetry and the Zeiss retinal vessel analyser.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Diagnostic
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