NCT04642612 - Clinical Trial References

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Citation(s)

Drummond JC
Cardiac Output: The Neglected Stepchild of the Cerebral Blood Flow Physiology Family. J Neurosurg Anesthesiol. 2020 Apr;32(2):93-94. doi: 10.1097/ANA.0000000000000677.
Fitch W, MacKenzie ET, Harper AM
Effects of decreasing arterial blood pressure on cerebral blood flow in the baboon. Influence of the sympathetic nervous system. Circ Res. 1975 Nov;37(5):550-7.
Meng L, Hou W, Chui J, Han R, Gelb AW
Cardiac Output and Cerebral Blood Flow: The Integrated Regulation of Brain Perfusion in Adult Humans. Anesthesiology. 2015 Nov;123(5):1198-208. doi: 10.1097/ALN.0000000000000872. Review.
Seltzer JL
Hoarseness and Horner's syndrome after interscalene brachial plexus block. Anesth Analg. 1977 Jul-Aug;56(4):585-6.
ter Laan M, van Dijk JM, Elting JW, Staal MJ, Absalom AR
Sympathetic regulation of cerebral blood flow in humans: a review. Br J Anaesth. 2013 Sep;111(3):361-7. doi: 10.1093/bja/aet122. Epub 2013 Apr 24. Review.

Cerebral Blood Flow Evaluation With Trancranial Doppler After Unilateral Interscalene Nerve Block: Observational Prospective Study

Clinical trial NCT04642612 - References