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MG4101 Plus Rituximab Including Lymphodepletion in Patient With r/r NHL B-cell Origin

Refractory Non-Hodgkin Lymphoma Clinical Trial

Official title:
Multi-center, Open-label, Phase 1/2a Clinical Trial to Evaluate the Efficacy and Safety of Combination Therapy With MG4101 Plus Rituximab in Patient With Relapsed/Refractory Non-Hodgkin's Lymphoma of B-cell Origin

Clinical Trial Summary

To determine the efficacy and safety of combined therapy of determined MG4101 dose and Rituximab.

Clinical Trial Description

This trial will consist of 3 parts; Phase 1 Maximum Tolerated Dose, Phase 1 extended cohort and Phase 2a.

For Phase 1, those who have a confirmed diagnosis of relapsed/refractory Non-Hodgkin's Lymphoma (NHL) of B-cell Origin of any subtype will be considered eligible for enrolment. Each cycle last approximately 28 days.

Once the dose of MG4101 is determined from Phase 1, Phase 2a will commence whereby two subgroups of patients will be enrolled and will similarly receive up to 6 cycles of treatment with the recommended Phase 2a dose of MG4101. The 2 subgroups are patients with indolent and aggressive NHL of B-cell origin respectively. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03778619
Study type Interventional
Source Green Cross LabCell Corporation
Contact
Status Active, not recruiting
Phase Phase 1/Phase 2
Start date November 28, 2018
Completion date October 30, 2020
View Details
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