Refractory Epilepsy Clinical Trial
Official title:
Study of Predictive Biomarkers for Rational Management of Drug-resistant Epilepsy Associated With Focal Cortical Dysplasia
Focal Cortical Dysplasias (FCDs) are neurodevelopmental disorders that represent a major cause of early onset drug-resistant epilepsies with cognitive and behavioral impairments, carrying a lifelong perspective of disability and reduced quality of life. Despite a major medical and socio-economic burden, rationale therapeutic strategies are still under debate. Surgical removal of the epileptogenic brain area (Epileptogenic Zone) is the most successful treatment, yet it fails to control FCD-associated seizures in as much as 40% of cases. Precise definition and complete resection of the Epileptogenic Zone are the main determinants of outcome. In current practice of French centers, up to 80% FCD-patients require an intracranial EEG (icEEG) recording to accurately define the epileptogenic zone. However, the indications for icEEG in MRI-visible FCD remain empirical and are essentially based on expert opinion.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02866240 -
Safety and Therapeutic Measures of Tdcs in Patients With Refractory Focal Epilepsy
|
N/A | |
| Withdrawn |
NCT04753983 -
A Study to Evaluate fMRI of Active DBS Stimulation in Epilepsy
|
N/A | |
| Completed |
NCT01899898 -
Efficacy of a Simplified Modified Atkins Diet in Children With Refractory Epilepsy
|
Phase 2/Phase 3 | |
| Recruiting |
NCT05493722 -
Optimization of Deep Brain Stimulation Parameters in Patients With Medically Refractory Epilepsy
|
Early Phase 1 | |
| Recruiting |
NCT03062514 -
Trial to Evaluate the Safety and Effectiveness of Vagus Nerve Stimulation for Children With Refractory Epilepsy
|
N/A | |
| Recruiting |
NCT04770337 -
Pivotal-Safety and Therapeutic Measures of tDCS in Patients With Refractory Focal Epilepsy
|
N/A | |
| Recruiting |
NCT05232630 -
Fenfluramine for the Treatment of Different Types of Developmental and Epileptic Encephalopathies: a Pilot Trial Exploring Epileptic and Non-epileptic Outcomes
|
Phase 4 | |
| Completed |
NCT04545346 -
The Potential of a Low Glutamate Diet as a Treatment for Pediatric Epilepsy
|
N/A | |
| Not yet recruiting |
NCT04542629 -
Comparative Study of Dietary and Immunological Management of Refractory Epilepsy in Children
|
Phase 4 | |
| Terminated |
NCT03570489 -
Randomized Controlled Trial on Cardiovascular Exercise in Uncontrolled Epilepsy:
|
N/A | |
| Completed |
NCT05031208 -
Acute and Long Term Effects of VNS on Memory in Patients With Refractory Epilepsy
|
N/A | |
| Completed |
NCT01880333 -
Evaluation of the Modified Atkins Diet in Young Children With Refractory Epilepsy
|
Phase 2/Phase 3 | |
| Completed |
NCT03676569 -
Intrathecal Autologous ADRC Treatment of Autoimmune Refractory Epilepsy
|
Phase 1 | |
| Withdrawn |
NCT03115489 -
Efficacy of Ketamine Infusion Compared With Traditional Anti-epileptic Agents in Refractory Status Epilepticus
|
Phase 2/Phase 3 | |
| Completed |
NCT02876289 -
Retrospective Evaluation of Perampanel in a French Neurology and Epileptology Department (Hospices Civil de Lyon)
|
N/A | |
| Completed |
NCT01521754 -
Product Surveillance Registry- Deep Brain Stimulation for Epilepsy
|
||
| Recruiting |
NCT04684797 -
Localization of the Reward Positivity to ACC
|
N/A | |
| Completed |
NCT05292183 -
Modulation of Emotion Perception in Humans Via Amygdala Stimulation
|
N/A | |
| Terminated |
NCT04398667 -
European Non-interventional Study on Refractory Epilepsy With Developmental Delay
|
||
| Active, not recruiting |
NCT04218812 -
Clinical Utility of Automated Electric Source Imaging in Presurgical Evaluation
|
N/A |