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Evaluation of Onfi Conversion Therapy Replacing Clonazepam in Patients With Medically Refractory Epilepsy

Refractory Epilepsy Clinical Trial

Official title:
Evaluation of Onfi Conversion Therapy Replacing Clonazepam in Patients With Medically Refractory Epilepsy: Efficacy, Tolerability, Dosing Equivalence, and Retention Rate

Clinical Trial Summary

The purpose of the study is to examine the clinical safety, tolerability, and efficacy of clobazam (Onfi) when it replaces the pre-existing clonazepam therapy in patients with refractory epilepsy.

Clinical Trial Description

The study is designed to answer frequently asked questions when clinicians replace existing 1,4-benzodiazepine to Onfi, as follows:

1. What should be the optimal equivalent doses for conversion?

2. How quickly should it be converted?

3. Would there be significant improvement of seizure control?

4. Should we expect difference in tolerability? If so, what are common adverse events?

5. Would the tolerance to the therapeutic effect differ with Onfi after conversion? ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01932502
Study type Interventional
Source St. Joseph's Hospital and Medical Center, Phoenix
Contact
Status Active, not recruiting
Phase Phase 4
Start date February 2013
Completion date September 2017
View Details
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