Refractory Chronic Cough Clinical Trial
Official title:
A Phase 3, 24-Week, Randomized, Double-Blind, Placebo-Controlled, Parallel-Arm Efficacy and Safety Study With Open-Label Extension of BLU-5937 in Adult Participants With Refractory Chronic Cough, Including Unexplained Chronic Cough
This is a randomized, double-blind, placebo-controlled, parallel-arm, Phase 3 study of BLU-5937 in participants with Refractory Chronic Cough (RCC).
The primary efficacy objective is to assess the effect of BLU-5937 on 24-hour cough frequency in adults with refractory chronic cough (including unexplained chronic cough) at 24 weeks. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03282591 -
Study of the Efficacy, Safety, and Tolerability of Serlopitant for the Treatment of Refractory Chronic Cough
|
Phase 2 | |
Completed |
NCT02476890 -
Effect of Gefapixant (MK-7264/AF-219) on Cough Reflex Sensitivity in Healthy and Chronic Cough Participants (MK-7264-014)
|
Phase 2 | |
Completed |
NCT03407014 -
Effect of Gefapixant (MK-7264/AF-219) on Cough Reflex Sensitivity in Healthy and Chronic Cough Participants (MK-7264-014)
|
Phase 2 | |
Recruiting |
NCT05599191 -
A 52-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough
|
Phase 3 | |
Recruiting |
NCT03662269 -
Indomethacin for Refractory Chronic Cough
|
Phase 3 | |
Recruiting |
NCT05962151 -
Refractory Chronic Cough Improvement Via NAL ER (RIVER)
|
Phase 2 | |
Recruiting |
NCT05110144 -
Efficacy of Two Doses of Duloxetine and Amitriptyline in Subjects With Refractory Chronic Cough
|
Phase 2 | |
Active, not recruiting |
NCT04882943 -
COllaboration REsearch on Chronic Cough (COREC): a French Multicenter Database
|
||
Enrolling by invitation |
NCT05733533 -
A Study to Assess the Efficacy and Tolerance of HRS-2261 in Subjects With Refractory Chronic Cough
|
Phase 2 | |
Completed |
NCT02349425 -
A Dose Escalation Study of Gefapixant (AF-219/MK-7264) in Refractory Chronic Cough (MK-7264-010)
|
Phase 2 | |
Completed |
NCT05628740 -
Placebo-controlled, Single and Multiple Dose Study in Healthy Volunteers and Refractory Chronic Cough Patients to Assess the Safety, Tolerability, and Pharmacokinetics of Two Formulations of NTX-1175
|
Phase 1 | |
Not yet recruiting |
NCT06213363 -
A Phase Ib/II Clinical Study in Patients With Refractory Chronic Cough
|
Phase 1/Phase 2 | |
Completed |
NCT02412020 -
Treatment of Refractory Chronic Cough With PA101
|
Phase 2 | |
Completed |
NCT04678206 -
Evaluation of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough
|
Phase 2 | |
Completed |
NCT02612623 -
An 8-Week Refractory Chronic Cough Study (MK-7264-021)
|
Phase 2 | |
Completed |
NCT02612610 -
A 12-Week Study in Participants With Refractory Chronic Cough (MK-7264-012)
|
Phase 2 | |
Completed |
NCT02397460 -
Effect of Gefapixant (AF-219/MK-7264) on Cough Reflex Sensitivity (MK-7264-015)
|
Phase 2 | |
Not yet recruiting |
NCT05265871 -
ATP Level and Cough Sensitivity to ATP in Subjects With Refractory Chronic Cough
|