Recurrent Neuroblastoma Clinical Trial
Official title:
Analysis of Circulating MYCN DNA in Serum Samples Obtained From Patients With Neuroblastoma
This research trial studies is deoxyribonucleic acid (DNA) in blood samples from patients with neuroblastoma. Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict how patients will respond to treatment.
OBJECTIVES:
I. Perform in a blind study a multicentric study by analyzing serum from patients at
diagnosis (with a known tumor v-myc avian myelocytomatosis viral oncogene neuroblastoma
derived homolog (MYCN) status determined in the Children's Oncology Group [COG] reference
lab), in order to confirm our previous data and to define the most appropriate MYCN/control
ratio cutoff capable of determining positive and negative cases.
II. Define the limits of the procedure in non-metastatic patients and in those with reduced
tumor burden (International Neuroblastoma Staging System [INSS] stage 1 and 2).
OUTLINE:
Circulating DNA is extracted from serum. Polymerase chain reaction (PCR) amplification of
MYCN is performed and analyzed by agarose gel electrophoresis. Real-time quantitative PCR is
also performed.
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Observational Model: Case-Only, Time Perspective: Retrospective
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