Recurrent Melanoma Clinical Trial
Official title:
A Pilot Study of Feasibility of Performing Intravital Microscopy in Melanoma Patients
This pilot clinical trial studies intravital microscopy for identifying tumor vessels in patients with stage IA-IV melanoma that is being removed by surgery. New imaging procedures, such as intravital microscopy, may determine the extent of melanoma.
PRIMARY OBJECTIVES:
I. To determine the feasibility of performing intravital microscopy on accessible human
melanoma tumors during their standard course of treatment (i.e., wide local excision). (Part
I)
SECONDARY OBJECTIVES:
I. To determine the blood flow velocity of the tumor vessels and tissue penetration of
fluorescein (fluorescein sodium) as a marker of tumor vessel permeability. (Part II)
OUTLINE:
Patients receive fluorescein sodium intravenously (IV) followed by intravital microscopic
observation over 10-15 minutes during excision of the melanoma.
After completion of study treatment, patients are followed up at 3 weeks and then
periodically for 5 years.
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