Rectal Neoplasms Clinical Trial
Official title:
Detection of CTCs in Stage III Rectal Cancer Patients Undergoing Neoadjuvant Therapy
The purpose of this study is to evaluate the value of dynamic change in detecting CTCs in peripheral blood from stage III rectal cancer patients undergoing neoadjuvant Folfox treatment and chemoradiotherapy,before and after surgery.
Circulating tumor cells (CTCs) have the potential to provide a surrogate for'real-time
biopsy' of tumor biological activity. Enumeration of CTCs in rectal cancer patients could
play an important role in diagnosis, predicting the risk for tumor recurrence and
effectiveness of neoadjuvant therapy.
The investigators choose several timepoints to detect the dynamic change of CTCs,1 day
before the 1st ,3rd and 5th(if the patient needs before surgery) neoadjuvant therapy
course,1 day before and 7days ,3 month,6 month after surgery. Approximately 7.5-mL ethylene
diamine tetraacetic acid(EDTA)-blood was drawn by vein puncture from patients with rectal
cancer . Briefly, the number of CTCs will be count by the cellsearch system , recorded and
analysed by the investigator.
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Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Screening
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