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Clinical Trial Summary

This study is to evaluate the disease control rate and time to progression of the sequential combination of oxaliplatin with an alternative anti-metabolite Trifluridine/tipiracil hydrochloride mixture, TAS-102,(TAS-OX) as well as irinotecan in combination with TAS-102 oxaliplatin(TAS-OX) + Bevacizumab in late-line metastatic colorectal cancer (mCRC)


Clinical Trial Description

This phase II trial will evaluate efficacy of TAS-OX alternating with TAS-IRI (sequential TASOXIRI) with Bevacizumab, in the treatment of mCRC. Participants will be treated with the study drugs until radiological evidence of disease progression or until treatment discontinuation secondary to adverse events. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05806931
Study type Interventional
Source Rutgers, The State University of New Jersey
Contact Howard S. Hochster, MD
Phone 732-253-5618
Email howard.hochster@rutgers.edu
Status Recruiting
Phase Phase 2
Start date May 17, 2023
Completion date May 1, 2027

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