| Eligibility |
Inclusion Criteria:
1. Rectal adenocarcinoma was confirmed pathologically;
2. Baseline clinical staging was T3-4 and/or N+, and rectal enhanced MRI was recommended
as staging standard;
3. distance from anus =12cm;
4. No distant metastasis;
5. Age 18-70, regardless of gender;
6. ECOG(Eastern Cooperative Oncology Group) score =1;
7. No chemotherapy or other anti-tumor therapy was used before inclusion;
8. Major organ functions within 28 days prior to treatment meet the following criteria:
A. Blood routine examination criteria (within 14 days without blood transfusion) :
Hemoglobin (HB) =80g/L, absolute value of neutrophil (ANC) =1.5×109/L, absolute value
of lymphocytes = the lower limit of normal value, platelet (PLT) =80×109/L; B.
Biochemical tests should meet the following criteria: Total bilirubin (TBIL) =1.5
times the upper limit of normal value (ULN); Alanine aminotransferase (ALT) and
aspartate aminotransferase (AST) =2.5×ULN; C. Coagulation tests should meet the
following standards: International standardized ratio (INR) or prothrombin time (PT)
=1.5 ULN; Activated partial thrombin time (APTT) =1.5 ULN (if the patient is on
anticoagulant therapy, as long as PT and APTT are within the expected treatment
range); D. Thyroid function: T3 and T4 levels were normal after drug treatment;
9. No history of autoimmune diseases or current autoimmune diseases;
10. Subjects must give informed consent to the study prior to the study and have
voluntarily signed a written informed consent;
11. The subjects can communicate well with the researcher and complete the study according
to the protocol; Women of reproductive age ;
12. should agree to use contraception (such as an intrauterine device, birth control pill
or condom) during the study period and 120 days after the end of the study; Serum or
urine pregnancy tests were negative during the 7 days prior to study enrollment.
Exclusion Criteria:
1. Patients who have previously received immune checkpoint inhibitors;
2. Known allergic reactions to PD-1 monoclonal antibody active ingredients, TKI
inhibitor-related ingredients or any excipients;
3. Patients with organ bleeding or bleeding tendency, except for rectal primary tumor
bleeding (need investigator to assess the risk of bleeding;
4. Pregnant or lactating women;
5. years or at the same time have a history of other malignant tumors, but cured skin
basal cell carcinoma and cervical carcinoma in situ and thyroid;
6. Patients with uncontrolled epilepsy, central nervous system disease or mental
disorders, the investigator judged that their clinical severity may hinder the signing
of informed consent or affect the patient 's compliance with oral drugs;
7. Clinically serious (i.e., active) heart disease, such as symptomatic coronary heart
disease, New York Heart Association (NYHA) class II or more severe congestive heart
failure or severe arrhythmia requiring drug intervention, or a history of myocardial
infarction within the last 12 months;
8. Subjects requiring systemic treatment with corticosteroids (greater than 10 mg
prednisone equivalent daily) or other immunosuppressive agents (including organ
transplant recipients) within 2 weeks before the first dose of study drug;
9. Participated in other interventional drug clinical trials within 4 weeks before the
first dose;
10. Major surgery or severe trauma within 4 weeks before the first dose of study drug;
11. Serious infection (CTCAE greater than grade 2) within 4 weeks before the first dose of
study drug,Such as severe pneumonia, bacteremia, infectious complications requiring
hospitalization; baseline chest imaging suggests active pulmonary inflammation,
symptoms and signs of infection within 2 weeks before the first dose of study drug, or
the need for oral or intravenous antibiotics (excluding prophylactic antibiotics);
12. Active autoimmune diseases, history of autoimmune diseases (such as interstitial
pneumonia, colitis, hepatitis, hypophysitis, vasculitis, nephritis, hyperthyroidism,
hypothyroidism, including but not limited to these diseases and syndromes);
autoimmune-mediated hypothyroidism treated with stable doses of thyroid replacement
hormone, using stable doses of insulin type 1 diabetes can be included; but excluding
vitiligo or recovered childhood asthma/allergy, without any intervention in adults;
13. History of immunodeficiency, including positive HIV test, or other acquired,
congenital immunodeficiency diseases, or history of organ transplantation and bone
marrow transplantation;
14. Active pulmonary tuberculosis infection found by medical history or CT examination, Or
patients with a history of active pulmonary tuberculosis infection within 1 year
before enrollment, or patients with a history of active pulmonary tuberculosis
infection but without regular treatment 1 year before enrollment;
15. Subjects with active hepatitis (HBV DNA = 2000 IU/ml or 10000 copies/ml), hepatitis C
(hepatitis C antibody positive,HCV-RNA was above the lower limit of detection of the
assay);
16. Had a known history of psychotropic drug abuse, alcoholism, or drug use;
17. Had a history, illness, treatment, or laboratory abnormality that could interfere with
the results of the trial, prevent the subject from participating throughout the study,
or the investigator considered participation to be in the subject 's best interest.
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