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The Exercise And Colorectal Cancer Treatment Trial — EXACT  

Rectal Cancer Clinical Trial

Official title:
The Exercise And Colorectal Cancer Treatment (EXACT) Trial

Clinical Trial Summary

This study will examine the biologic processes through which exercise may prevent disease recurrence in patients who have completed treatment for colorectal cancer.

Clinical Trial Description

This randomized trial will examine the biological effects of 12-weeks of moderate-intensity aerobic exercise versus wait-list control in 60 subjects who have completed standard medical therapy for colorectal cancer. The primary objective is to determine if aerobic exercise can reduce systemic inflammation, quantified using plasma concentrations of high-sensitivity C-reactive protein and interleukin-6. The secondary objectives are to determine if exercise can reduce: 1) insulin resistance quantified using an oral glucose tolerance test, and; 2) circulating tumor cells quantified using a microfluidic antibody-mediated capture platform. The exploratory objective is to determine if exercise can improve mitochondrial respiration rates and fatty acid oxidation in peripheral blood mononuclear cells and tumor fraction. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03975491
Study type Interventional
Source Pennington Biomedical Research Center
Contact
Status Active, not recruiting
Phase N/A
Start date August 16, 2019
Completion date April 30, 2025
View Details
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