Rectal Cancer Clinical Trial
Official title:
A Registry Based Study of Clinical Results and of Health and Wellbeing in Patients After Abdominoperineal Resection for Rectal Cancer
The aim of the project is to evaluate the oncological and functional outcome of the more
extensive perineal dissection - i.e the extra levator resection - in abdominoperineal
resections in patients with rectal cancer.
Hypothesis: Extra levator perineal resection reduces local recurrence three year
postoperatively compared to traditional abdominoperineal resection and improves QoL 2-4
years postoperatively.
Low rectal cancer treated surgically by abdominoperineal resection (APR) has worse outcome
than other rectal cancers operated with low anterior resection. In order to improve the
outcome in the APR group a more extensive surgical procedure - the extra levator APR - has
been suggested. This study aims to investigate both the oncological and the functional
outcome of this method as compared to the traditional APR.
Method: All Swedish patients undergoing abdominoperineal resection for rectal cancer
2007-2009 will be analysed regarding operative technique (traditional or extra levator
resection). Data on all patients regarding pre op TNM classification, pathological report
and local recurrence will be collected from the Swedish Rectal Cancer registry. A validated
QoL form will be sent to each patient to further investigate the functional outcome, health
economy and Quality of Life 2-4 years postoperatively.
Data will be analysed regarding 3 year recurrence rate (primary endpoint) as well as
functional result and QoL (secondary endpoints) in the two different groups - i.e
traditional and extra levator APR.
;
Observational Model: Case Control, Time Perspective: Retrospective
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