Rectal Cancer Clinical Trial
Official title:
Short-course Preoperative Chemoradiotherapy Followed by Delayed Operation for Locally Advanced Rectal Cancer: Phase II Multi-institutional Study
Concurrent chemoradiotherapy (CRT)
- Radiotherapy 25 ㏉/5 fractions (start concomitantly at D1)
- ↓ ↓ ↓ ↓ ↓
- Radical surgery 6 weeks after completion of chemoradiotherapy
- ↑ ↑ ↑ ↑ ↑ D1 - - - - - D5
- 5-Fluorouracil 400㎎/㎡/day + LV 20㎎/㎡/day IV bolus during the radiotherapy
Radiotherapy using tomotherapy is delivered in 5 Gy daily fractions for a total of 25 Gy in
5 fractions.
A bolus injection of 5-fluorouracil (400 mg/m2/d)and leucovorin (20 mg/m2/d) is delivered
concurrently on day 1-5 during radiotherapy.
Total mesorectal excision is performed within 6±2 weeks. The pathological response of
downstaing is the study endpoint.
;
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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