Rectal Cancer Clinical Trial
Official title:
An Open-label, Multicenter, Randomized Phase 2 Study Evaluating the Safety and Efficacy of 5 FU/FA and Oxaliplatin (Modified FOLFOX 6) in Combination With Ramucirumab or IMC-18F1 or Without Investigational Therapy as Second Line Therapy in Patients With Metastatic Colorectal Cancer Following Disease Progression on First Line Irinotecan-based Therapy
The purpose of this study is to determine if participants with metastatic colorectal cancer live longer without their cancer progressing when treated with standard chemotherapy, standard chemotherapy plus ramucirumab, or standard chemotherapy plus icrucumab.
The purpose of this study is to evaluate the progression-free survival (PFS) in participants
with metastatic colorectal cancer when treated with 1 of 3 modified FOLFOX-6 (folinic acid
[FA] + fluorouracil [5-FU] + oxaliplatin [mFOLFOX-6])-based regimens, as second-line therapy.
During 2010, there has been an identified shortage of injectable folinic acid (FA) in the
United States. Levo-folinic acid (LFA) will be allowed as a substitute for FA in the
mFOLFOX-6 chemotherapy regimen in circumstances in which FA is not available, to facilitate
continuity of participant care.
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