Avoiding Surgery in Rectal Cancer After Pre-Operative Therapy

Status Unknown status

Clinical Trial Summary

The objective of Timing and Deferral of Rectal Surgery Following a Continued Response to Pre-operative CRT study is to establish the time to maximum tumour response following CRT, and to investigate whether surgery can be safely avoided within the tight framework of the trial follow-up protocol in a small group of patients where the cancer becomes undetectable by imaging modalities.

Clinical Trial Description

The study uses MRI in combination with FDG-PET CT and clinical examination (tri-modality assessment) to assess for a continued incremental response to CRT. Surgery is NOT withheld from patients entering this study. Indeed, surgery is an option at each stage of patient follow-up and is a crucial component of a patient's treatment pathway should no further regression of disease be detected through stringent follow-up. If a status of 'no detectable disease' by serial MRI, CT-PET and clinical assessment is achieved and the patient wishes not to have surgery, they will continue to be carefully monitored within the framework of the trial follow-up protocol. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01047969
Study type	Interventional
Source	Royal Marsden NHS Foundation Trust
Contact
Status	Unknown status
Phase	Phase 2
Start date	June 6, 2006
Completion date	June 2019

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