Recovery Clinical Trial
Official title:
Efficacy of a Controlled Short-term Trial of Cannabidiol (CBD) Ingestion on Reducing Symptomatic Response and Facilitating Recovery After Induced Muscle Injury
The study aims to determine the efficacy of a controlled short-term trial of CBD ingestion for reducing symptomatic response and facilitating recovery following induced muscle injury. A double-blind, randomized, three-arm study design will be used and participants will be randomly assigned to either a high dose (n=15), low dose (n=15), or vehicle control group (n=15). The clinical outcomes include measures of muscular pain and disability along with measures of pain-related fear and anxiety.
Current research has shown evidence that phytocannabinoids may have a promising therapeutic potential in a variety of physical and psychological ailments, and cannabidiol (CBD) is of particular interest due to its positive safety profile, non-intoxicating effects and widespread capabilities in a number of musculoskeletal diseases. Three primary reasons people consume CBD on a global basis, in addition to the fact that it is non-intoxicating, are for symptomatic (pain) relief, anxiety reduction, and improved sleep quality. Very little is known about CBD and how it functions in the body from both an efficacy and mechanistic perspective, especially in humans. There is a large consumer base for this product that will be expanding exponentially in the next few years. Most of the evidence available is anecdotal from the personal testimony of consumers. We aim to determine the efficacy of a controlled short-term trial of CBD ingestion for reducing symptomatic response and facilitating recovery following induced muscle injury. In addition, we aim to identify if the effects are dose-dependent by utilizing a low-dose (25 mg/day), high-dose (62.5 mg/day) and vehicle-control (0 mg/day) ingestion regimen. We will assess, in serial fashion, symptomatic response, functional limitations and recovery of the quadriceps muscle following induced injury in which selected doses of CBD oil will be administered orally during a 15-day pre-injury consumption and post-injury recovery phase. A double-blind, randomized, three-arm study design will be used and participants will be randomly assigned to either a high dose (n=15), low dose (n=15), or vehicle control group (n=15). Our clinical outcomes include measures of muscular pain and disability along with measures of pain-related fear and anxiety. Our laboratory-based study design is desirable and advantageous because it is a controlled method of tracking individuals using an experimental model of injury that is translatable to clinical populations. Another advantage of this study design is that it will address, in parallel fashion, two of the primary reasons people are consuming CBD - symptomatic relief and anxiety reduction. This exploratory study will provide preliminary data needed to support the hypotheses of a planned larger scale application. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03708692 -
Menstrual Cycle Phases on Recovery and Cognitive Function
|
||
Completed |
NCT06012747 -
Pain After Cesarean Section - A Danish Multicenter Cohort Study.
|
||
Recruiting |
NCT04049942 -
Comparing the Impact of Multimodal Prehabilitation to Aerobic Training on Patients Undergoing Thoracoscopic Lobectomy
|
N/A | |
Completed |
NCT04564300 -
The Influence of Oral Contraceptive Use on Muscle Recovery
|
N/A | |
Active, not recruiting |
NCT06160869 -
Effect of Acceptance and Commitment Therapy on Psychotic Severity
|
N/A | |
Completed |
NCT04082728 -
Evaluation of the Added Value of Metamizole to Standard Post-operative Treatment After Ambulant Surgery
|
N/A | |
Completed |
NCT03775564 -
Effectiveness of the RemedRugby Program
|
N/A | |
Completed |
NCT01902147 -
Postoperative Quality Recovery Scale (PQRS)
|
N/A | |
Completed |
NCT05607875 -
The Grow to Recovery Train-the-Trainer Program
|
N/A | |
Completed |
NCT05097027 -
Blood Flow Restriction and Recovery in Soccer Players
|
N/A | |
Recruiting |
NCT04549610 -
HMB and Exercise-induced Muscle Damage
|
Phase 2/Phase 3 | |
Withdrawn |
NCT04125225 -
What Are the Experiences of Patients With Pseudomyxoma Peritonei?
|
||
Recruiting |
NCT04092504 -
Optimized Recovery After Trauma in Geriatric Patient
|
N/A | |
Completed |
NCT06112210 -
Effect of Hyperbaric Oxygen Therapy
|
N/A | |
Active, not recruiting |
NCT06440343 -
Effects of Acute Carbohydrate Intake Intra-training in Crosstraining
|
N/A | |
Completed |
NCT05998590 -
Pre-sleep Protein Supplementation in British Army Recruits
|
N/A | |
Active, not recruiting |
NCT05984186 -
Wingate-type Exercise Test to Evaluate the Effect of High Velocity Therapy on Recovery Sensation and Blood Lactate Decline
|
||
Recruiting |
NCT04297852 -
The Function of Nutrition Rich Vegan Drink on Inflammatory Bowel Disease
|
N/A | |
Completed |
NCT06206798 -
Resourcefulness Group Intervention on Recovery and Quality of Life
|
N/A | |
Completed |
NCT02132481 -
Using Smartphones to Provide Recovery Support Services
|
N/A |