Recovery From Anesthesia Clinical Trial
Official title:
Improved Patient Recovery of Spontaneous Respiration After Anesthesia With Hypercapnic Hyperpnoea
The proposed study will measure the incidence of adverse events and the decrease in time to meet discharge criteria from the post anesthesia care unit when hypercapnic and hyperpnoea are used during emergence.
Hypercapnia has been used in conjunction with hyperpnoea to provide a more rapid return of
responsiveness after inhaled anesthesia. The benefits of accelerating patient recovery in
the operating room may extend to the post anesthesia care unit if the patient is more alert
and easier to care for when they arrive in the unit. Respiratory patterns and gas levels -
including CO2, O2, and anesthetic vapor - will be measured in order to better understand a
patient's respiratory status during recovery.
In Feb 2009 we finished our first study (IRB 26111) and submitted a publication. The journal
reviewers identified a serious limitation: we could not report whether the treated patients
recovered from anesthesia faster because the treatment (inspired CO2) caused them to breath
more vigorously or because the treatment caused the anesthetic vapors to be cleared more
rapidly from the brain. Our new application uses essentially the same study protocol as the
former study but adds chest bands to measure the patient's rate of breathing and expired gas
monitoring to measure the rate at which the vapors are removed.
;
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Investigator, Outcomes Assessor), Primary Purpose: Basic Science
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT04151381 -
The Effect of Preoperative Aminophylline
|
Phase 1 | |
| Completed |
NCT01851005 -
Effect of Dexmedetomidine on Recovery Profiles of Elderly Patients
|
N/A |