Raynaud Phenomenon Clinical Trial
Official title:
Comparison of Phosphodiesterase-5 Inhibitor and Calcium Channel Inhibitor for the Treatment of Secondary Raynaud Phenomenon, Double Blind, Randomized, Cross-over Trial
The prevalence of Raynaud phenomenon (RP), a reversible vaso-constriction with skin
discoloration, is 5-10% in general population. Often conventional measures such as warming
up or minimizing exposure to cold are not enough and many patients require treatment with a
vasodilator therapy. A recent study showed a good efficacy and safety profile of sildenafil,
a selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) in RP.
Here, the investigators aim to examine the efficacy and safety of Udenafil, a newer PDE5
inhibitor, as compared to amlodipine, a well known calcium channel blocker, in the treatment
of secondary RP in Korean patients.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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