Radiography Clinical Trial
— LOOPINGOfficial title:
Non Invasive Pressure -Volume Loop (PVLOOP) With 3D Echocardiography and Arterial Tonometry
In patients under general anesthesia, the prevention of intraoperative hypotension to maintain blood pressure (BP) close to the initial blood pressure, i.e. before anesthesia, is essential to reduce the risk of death and improve surgical outcomes. Vasoactive agents are commonly used to correct this hypotension (Phenylephrine Ephedrine Noradrenaline). These three vasoconstrictors have specific effects on the afterload of the heart and can impair its function. The analysis of the left ventricular pressure-volume curve (PV Loop) allows continuous information on the post-charge state of the left ventricle and the changes induced by the vasoconstrictors to be observed. However, the investigators currently have no way of monitoring these effects. In clinical practice if these loops are obtained non-invasively they can be used in the evaluation of cardiac function of at-risk patients in perioperative and also in intensive care to allow therapeutic adaptation.
Status | Recruiting |
Enrollment | 55 |
Est. completion date | July 2023 |
Est. primary completion date | January 2023 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Patients > 18 years, scheduled for an elective interventional neuroradiology procedure under general anesthesia requiring a continuous monitoring of mean arterial pressure and cardiac output. Exclusion Criteria: - age <18 years - Patient who has not signed the consent - Pregnant woman - Patient under judicial protection - Patient without affiliation to a social security scheme |
Country | Name | City | State |
---|---|---|---|
France | Department of Anesthesiology and Intensive Care, Lariboisière Hospital | Paris |
Lead Sponsor | Collaborator |
---|---|
Assistance Publique - Hôpitaux de Paris | INSERM UMR-942, Paris, France, M3DISIM |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Aortic pressure in the descending thoracic aorta in mmHg (PAo) | For all patients, aortic pressure will be collected at the end of the procedure during catheter withdrawal | Duration of the interventional neuroradiology procedure (maximum 1 day) | |
Primary | Aortic velocity in the descending aorta in cm/s (VAdes.) | For all patients, aortic descending velocity will be collected at the end of the procedure during catheter withdrawal. | Duration of the interventional neuroradiology procedure (maximum 1 day) | |
Primary | Central pressure by tonometry (CP in mmHg) | For all patients, central pressure by tonometry will be collected at the end of the procedure. | Duration of the interventional neuroradiology procedure (maximum 1 day) | |
Primary | Ventricular diastolic pressure (VdP in mmHg) | For all patients, ventricular diastolic pressure by 3D echocardiography will be collected at the end of the procedure. | Duration of the interventional neuroradiology procedure (maximum 1 day) | |
Primary | Left ventricular volume (LVV in mL) | For all patients, left ventricular volume by 3D echocardiography will be collected at the end of the procedure. | Duration of the interventional neuroradiology procedure (maximum 1 day) |
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