Radiography Clinical Trial
— VPLOOPOfficial title:
Cardiac Afterload Indices Measured in Ascending and Descending Aorta: Rational for the Use of Velocity-Pressure Loop in the Operating Room
NCT number | NCT03853226 |
Other study ID # | SRLF 11-356 |
Secondary ID | |
Status | Completed |
Phase | |
First received | |
Last updated | |
Start date | January 5, 2014 |
Est. completion date | March 25, 2016 |
Verified date | February 2019 |
Source | Hopital Lariboisière |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
In surgical patients considered with "high cardiovascular risk", by their field or by the
nature of their intervention, it is recommended to use hemodynamic monitoring including a
continuous measurement device of arterial pressure and cardiac output (CO). However,
targeting mean arterial pressure (MAP) with boluses of selective peripheral vasopressors
(without positive inotropic or chronotropic effects) could have deleterious effects on CO.
Thus, it seems important to use a combined analysis of MAP and CO to estimate the
afterload-related cardiac performance (ACP) The investigators recently proposed a cardiac
afterload monitoring, in the descending thoracic aorta, based on a combined analysis of flow
velocity signal recorded by trans-oesophageal Doppler and aortic pressure, the
Velocity-Pressure Loop (VP Loop). VP Loop, and its derived indicators, especially Global
AfterLoad Angle (GALA), could be useful during hemodynamic management for continuous cardiac
afterload monitoring. However, in cardiology unit, cardiac afterload is usually measured at
the ascending aorta behind the aortic valves.
The main objective of this study is to compare VP Loop parameters build in the ascending and
descending thoracic aorta according to patient cardiovascular risk factors.
Status | Completed |
Enrollment | 55 |
Est. completion date | March 25, 2016 |
Est. primary completion date | January 25, 2016 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - • Patients > 18 years scheduled an elective interventional neuroradiology procedure under general anesthesia requiring a continuous monitoring of mean arterial pressure and cardiac output. - oral agreement obtained from each patient before anesthesia Exclusion Criteria: - • age <18 years - an emergency procedure |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Joaquim MATEO | INSERM UMR-942, Paris, France, LMS Polytechnique and M3DISIM, Inria, Université Paris-Saclay |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Measure of aortic pressure in the ascending aorta and in the descending thoracic aorta in mmHg (PAo) | For all patients, aortic pressure will be collected at the end of the procedure during catheter withdrawal | Duration of the surgical intervention or interventional neuroradiology procedure (maximum 1 day)] | |
Primary | Aortic velocity in the ascending aorta in cm/s (VAasc.) | For all patients, aortic ascending velocity will be collected at the end of the procedure during catheter withdrawal | Duration of the surgical intervention or interventional neuroradiology procedure (maximum 1 day) | |
Primary | Aortic velocity in the descending aorta in cm/s (VAdes.) | For all patients, aortic descending velocity will be collected at the end of the procedure during catheter withdrawal | Duration of the surgical intervention or interventional neuroradiology procedure (maximum 1 day)] |
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