Clinical Trials Logo
  1. Home
  2. Radiation
  3. NCT05669092

A Phase III Trial of Anus-preservation in Low Rectal Adenocarcinoma Based on MMR/MSI Status

Radiation Clinical Trial

Official title:
A Randomized, Controlled, Open-label, Multicenter, Phase III Trial of Anus-preservation in Low Rectal Adenocarcinoma Based on MMR/MSI Status(APRAM)

Clinical Trial Summary

pMMR/MSS and 32 dMMR/MSI-H patientspatients were planned to be enrolled. Patients with dMMR/MSI-H will be randomly assigned to the immunotherapy arm or short-course radiotherapy sequential immunotherapy arm; pMMR/MSS patients will receive capecitabine-irinotecan based concurrent radiotherapy before being randomly assigned to the XELIRI or FOLFRINOX arm. The rate of complete response (sustained cCR for ≥ 1 year), long-term prognosis and adverse effects will be analyzed.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05669092
Study type Interventional
Source Zhejiang Cancer Hospital
Contact JI ZHU
Phone 13501978674
Email zhuji@zjcc.org.cn
Status Recruiting
Phase Phase 3
Start date November 1, 2022
Completion date December 31, 2025
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT06214611 - Prospective Validation of Adaptive Radiotherapy (ART) in Patients With Head and Neck Tumors N/A
Completed NCT02834897 - Performance Evaluation of System EOS Imaging in Pelvimetry Versus Pelvi-scanner N/A
Completed NCT02188563 - A Comprehensive Smoking Cessation Intervention Duration Radiation for Upper Aerodigestive Cancers N/A
Recruiting NCT03920033 - Salvage Hypofractionated Accelerated Versus Standard Radiotherapy for Biochemical Failure After Prostatectomy N/A
Recruiting NCT03468010 - A Trial Comparing Adjuvant Chemotherapy With Observation After Concurrent Chemoradiotherapy of Cervical Cancer (With Pelvic or Para-aortic Node Involvement) Phase 3
Completed NCT03235427 - The CAROLE (CArdiac Related Oncologic Late Effects) Study
Active, not recruiting NCT06295783 - Prospective Evaluation of the Relation Between Different Questionnaires Measuring Radiation-induced Side-effect
Not yet recruiting NCT06253338 - Optimization of Radiation Protection Through Genomic Analyses N/A
Completed NCT03461341 - European iNvestigation of SUrveillance After Resection for Esophageal Cancer
Recruiting NCT02993653 - Intensity-modulated Radiotherapy Protocol in Cervix Cancer Phase 2
Recruiting NCT01284153 - Potential Benefits of Radiotherapy in Prone Position for Breast Cancer Patients: a Planning Study N/A
Recruiting NCT06230549 - Adaptive Radiotherapy in Patients With Gynecological Tumors N/A
Completed NCT03735706 - Relationship Between Contrast Media Volume and Tube Voltage in CT for Optimal Liver Enhancement, Based on Body Weight. N/A
Completed NCT03259126 - EXTended pRotective Curtain Under Table to Reduce Operator RAdiation Dose in Percutaneous Coronary Procedures N/A
Completed NCT03581110 - CODP Imaging From a Dose Perspective
Recruiting NCT04069884 - RecurIndex Guided Avoidance of Regional Nodal Irradiation for Node Positive Breast Cancer N/A
Recruiting NCT04967976 - Breast Mesh Used in Two-staged Breast Reconstruction N/A
Terminated NCT01099020 - Temporal Pattern of Circulating DNA for Patients Receiving Irradiation N/A
Not yet recruiting NCT04814069 - A Multicenter Phase II Trial of Post-operative Concurrent Chemoradiotherapy Using Weekly Cisplatin With Tislelizumab for Patients With High-risk Head and Neck Squamous Cell Carcinoma：The POTENTIAL Study Phase 2
Recruiting NCT03484221 - Totally Neoadjuvant FOLFOXIRI + Short-course Radiation + XELOX in Patients With Locally Advanced Rectal Cancer Phase 2