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Cardiotoxicity in Locally Advanced Lung Cancer Patients Treated With Chemoradiation Therapy — CLARITY  

Radiation Toxicity Clinical Trial

Official title:
Cardiotoxicity in Locally Advanced Lung Cancer Patients Treated With Chemoradiation Therapy: A Prospective Longitudinal Cohort

Clinical Trial Summary

This observational cohort will evaluate the cardiovascular effects of chemoradiation used to treat locally advanced, non-small cell lung cancer. Patients will be enrolled prior to the start of therapy and followed during and for at least 2 years after therapy with echocardiograms, nuclear stress tests, blood sampling, and quality of life surveys.

Clinical Trial Description

Lung cancer is both the most common malignancy worldwide and the leading cause of cancer death in the US. While radiation therapy is highly effective for many solid tumors, thoracic radiation therapy carries a risk of cardiovascular morbidity and mortality that limits critical gains in cancer control and survival. The investigators will perform detailed cardiovascular phenotyping using biologic and imaging markers to define functional and physiologic perturbations that occur with radiation therapy. The study will provide insights into how cardiovascular risk factors and disease impact these biologic and functional changes. The investigators will also determine which radiotherapy dose-volume metrics are indicative of subclinical cardiotoxicity. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04305613
Study type Observational
Source Abramson Cancer Center at Penn Medicine
Contact
Status Enrolling by invitation
Phase
Start date September 14, 2020
Completion date December 2028
View Details
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