Normal Tissue Oxygenation Following Radiotherapy

Status Completed

Clinical Trial Summary

This study involves women who have had a diagnosis of breast cancer, and have had a lumpectomy with radiation treatments completed in the past year. The study will determine the level of oxygen in the skin of the breast that has been radiated, compared with the normal skin of the opposite breast. The purpose of this study is to determine if there is a decrease in oxygen levels in the skin which has been radiated, hopefully to find a treatment to limit skin damage caused by radiation treatments, for women with breast cancer in the future.

Clinical Trial Description

Successful completion of this study will provide data on changes in oxygenation in irradiated tissues. If changes are documented, this study would provide evidence supporting current models of tissue injury following radiotherapy. In addition, these data may provide a mechanistic rationale for clinical approaches to ameliorate the toxicities of radiotherapy. Finally, if a correlation exists between tissue oxygenation and toxicity, the rapid and simple tissue oxygenation test may provide a quantitative measure of toxicity and allow earlier and more precise assessment of both toxicity and efficacy of ameliorative therapies. ;

Study Design

Related Conditions & MeSH terms

Radiation Toxicity

Clinical Trial Details

NCT number	NCT00677040
Study type	Observational
Source	Essentia Health
Contact
Status	Completed
Phase
Start date	April 2008
Completion date	August 2009

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04059809` - Photobiomodulation for Breast Cancer Radiodermatitis	Phase 2/Phase 3
Recruiting	`NCT03876860` - An Enhanced Vaginal Dilator to Reduce Radiation-Induced Vaginal Stenosis	N/A
Completed	`NCT02058550` - Phone or Email Reminder in Increasing Vaginal Dilator Use in Patients With Gynecologic Cancers Undergoing Brachytherapy	Phase 1
Completed	`NCT01399372` - Rituximab, Methotrexate, Vincristine Sulfate, Procarbazine Hydrochloride, and Cytarabine With or Without Radiation Therapy in Treating Patients With Primary Central Nervous System Lymphoma	Phase 2
Completed	`NCT01434290` - Radiation Therapy in Treating Patients With Prostate Cancer	Phase 2
Active, not recruiting	`NCT00087815` - Hyperbaric Oxygen Therapy in Treating Patients With Radiation Necrosis of the Brain	N/A
Completed	`NCT01407770` - Genetic Susceptibility to Radiation-Induced Skin Reactions in Racial/Ethnic Groups of Patients With Breast Cancer
Completed	`NCT00003313` - Amifostine in Treating Patients With Stage II or Stage III Non-small Cell Lung Cancer	Phase 3
Completed	`NCT03783364` - Pre- or Postoperative Accelerated Radiotherapy	N/A
Enrolling by invitation	`NCT04305613` - Cardiotoxicity in Locally Advanced Lung Cancer Patients Treated With Chemoradiation Therapy
Recruiting	`NCT06036706` - Neurocognitive Impact of Different Irradiation Modalities for Patients With Grade I-II Skull Base Meningioma:	N/A
Withdrawn	`NCT04593914` - A Novel Skin Barrier Protectant for Acute Radiodermatitis	N/A
Recruiting	`NCT04110223` - Validation Studies of Biomarkers for Precision Radiation Oncology in Locally Advanced Solid Tumors
Active, not recruiting	`NCT02259218` - Metabolomic and Epigenetic Profiling of Bodyfluids From Lung and Brain Cancer Receiving Radiation Therapy
Recruiting	`NCT06073509` - Atrial Fibrillation and Other Cardiac Arrhythmias and Diseases After Radiotherapy for Breast Cancer : Watch Your HeaRT
Withdrawn	`NCT02017925` - Pulmonary Rehabilitation in Improving Lung Function in Patients With Locally Advanced Non-Small Cell Lung Cancer Undergoing Chemoradiation	N/A
Completed	`NCT01170299` - Low-Fiber Diet or High-Fiber Diet in Preventing Bowel Side Effects in Patients Undergoing Radiation Therapy for Gynecological Cancer, Bladder Cancer, Colorectal Cancer, or Anal Cancer	N/A
Completed	`NCT00974168` - Spinal Cord Compression Re-Treat Study	Phase 2
Completed	`NCT00008398` - Sargramostim in Decreasing Mucositis in Patients Receiving Radiation Therapy for Head and Neck Cancer	Phase 3
Enrolling by invitation	`NCT04047823` - Temperature and Injury in Radiotherapy Radiation Skin Injury