Radiation Injury Clinical Trial
Official title:
Differentiation of Pseudoprogression and True Progression Through High Field Susceptibility Weighted Imaging and R2*
Using a multi-echo gradient echo sequence to calculate R2* and quantitative susceptibility maps and well as susceptibility-weighted imaging post processing the investigators hypothesize that the investigators would be able to distinguish between pseudoprogression and true progression with the use of an easily implementable sequence on clinical MRI scanners.
Post-treatment radiographic imaging change (PTRIC) is seen in approximately 50% of patients who are treated for brain neoplasms using chemotherapy and radiotherapy. PTRIC can be attributed to true disease progression or a form of benign radiographic enhancement, known in literature as pseudoprogression. Of these patients, 50% of them have benign radiographic enhancement that is usually spontaneously resolved and required no intervention. The other 50% require immediate medical intervention, or more aggressive treatment for true progression. Currently standard medical practise is to administer a prophylactic treatment of chemotherapy to all patients with PTRIC with a follow up scan 3-6 months after initial PTRIC diagnosis, leading to up to 50% of patients receiving an unneeded dose of chemotherapy. The investigators hope to take advantage of the differentiation in tissue types and vascularization between true progression tumour and pseudoprogression to be able to identify patients who would not need to be administered a prophylactic dose of chemotherapy. ;
Observational Model: Case-Only, Time Perspective: Cross-Sectional
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT02152722 -
Breath Test for Biomarkers in Humans Receiving Total Body Irradiation
|
N/A | |
Completed |
NCT00760409 -
Differentiating Recurrent Brain Tumor Versus Radiation Injury Using MRI
|
N/A | |
Withdrawn |
NCT00745641 -
Abdominal Computed Tomography and the Blood Reactive Oxygen Species Level
|
N/A | |
Active, not recruiting |
NCT02725840 -
Breast Cancer Lung Late Effects
|
||
Completed |
NCT02478255 -
Longitudinal MR Imaging of Pulmonary Function in Patients Receiving Thoracic Radiation Treatment
|
Phase 2 | |
Withdrawn |
NCT00815230 -
Effect of Cardiac Computed Tomography Angiography on the Blood Reactive Oxygen Species Level
|
N/A | |
Completed |
NCT01334931 -
Use of Large Field of View During Image Acquisition for Coronary Angiography
|
Phase 3 |