Pulp Necrosis Clinical Trial
Official title:
Evaluation of Post-Operative Pain After Regenerative Endodontic Using Photo-Activated Oral Disinfection Versus Triple-Antibiotic Paste for Management of Necrotic Young Permanent Anterior Teeth
This study aims to compare regenerative endodontics for necrotic young permanent anterior
teeth using oral photo-activated disinfection versus triple antibiotic paste in terms of:
1. Clinical success in terms of absence of any complication such as spontaneous pain, sinus
or swelling.
2. Radiographic success in terms of healing of periapical radiolucency or increase root
thickness, length or apical closure.
Disinfection of the root canal system is thought to be critical to the success of
Regenerative Endodontic Procedures (REPs) as infection prevents regeneration, repair and stem
cell activity . A suitable material for using as intra-canal medicament seems to be
antibiotic. Triple antibiotic paste (TAP) containing metronidazole, ciprofloxacin and
minocycline has been reported to be a successful regimen in controlling the root canal
pathogen and in managing necrotic young permanent tooth .
Recently, new disinfection methods have been developed to overcome the limitations of
conventional disinfecting protocols that they may neither reduce the number of bacteria to a
satisfactory level nor minimize the toxicity to periapical stem/progenitors . Other concerns
regarding the use of TAP are tooth discoloration after treatment and bacterial resistance.
Photo-activated oral disinfection is a novel disinfection method which present a great
solution for the problem associated with triple antibiotic paste
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