Pulmonary Sarcoidosis Clinical Trial
Official title:
Controlled Trial of Serologic Efficacy of Influenza Vaccine in Patients With Sarcoidosis
The purpose of this study is to determine the efficacy of influenza vaccine (antibody response) in patients with sarcoidosis.
Sarcoidosis is a multisystem disease with unclear etiology characterized by the presence of
noncaseating granuloma[1]. T helper cells response is exaggerated at the site of disease and
cellular immunity depressed in peripheral blood[2]. Cutaneous anergy, lymphopenia and
inversion of CD4/CD8 ratio in peripheral blood suggest T helper cells involvement[3].
The action of humeral immune system in sarcoidosis is a matter of controversy. Standard
hepatitis B virus vaccination did not provoke protective antibody titer in patients with
sarcoidosis[3]. Although antibody response against influenza vaccine in patients with
sarcoidosis is not well described, this vaccine is highly recommended in patients with
chronic pulmonary diseases such as asthma, COPD and fibrosis [4, 5, 6]. In this study we aim
to evaluate the humeral response to the influenza vaccine in sarcoidosis patients and assess
vaccine safety.
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Observational Model: Case Control, Time Perspective: Prospective
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